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FT-671

CAS No. 1959551-26-8

FT-671 ( FT671;FT 671 )

产品货号. M13072 CAS No. 1959551-26-8

FT-671 is a novel potent, specific, non-covalent USP7 inhibitor with Kd of 65 nM (USP7 catalytic domain).

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥11097 有现货
50MG ¥22518 有现货
100MG ¥29970 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    FT-671
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    FT-671 is a novel potent, specific, non-covalent USP7 inhibitor with Kd of 65 nM (USP7 catalytic domain).
  • 产品描述
    FT-671 is a novel potent, specific, non-covalent USP7 inhibitor with Kd of 65 nM (USP7 catalytic domain); inhibits USP7 with IC50 values of 52 nM (USP7 CD) and 69 nM (USP7C-term), display good USP7 selectivity in a panel of 38 deubiquitinases (DUBs); destabilizes USP7 substrates including MDM2, increases levels of p53, and results in the transcription of p53 target genes and induces tumour suppressor p21; blocks the proliferation of MM.1S cells (IC50=33 nM), suppresses tumour growth in mice; orally available.
  • 同义词
    FT671;FT 671
  • 通路
    Proteasome/Ubiquitin
  • 靶点
    DUB
  • 受体
    DUB
  • 研究领域
    Cancer
  • 适应症
    ——

化学信息

  • CAS Number
    1959551-26-8
  • 分子量
    533.49
  • 分子式
    C24H23F4N7O3
  • 纯度
    >98% (HPLC)
  • 溶解度
    ——
  • SMILES
    O=C1C2=C(N=CN1CC3(CCN(CC3)C(C[C@@H](C(F)F)N4N=C(C=C4)F)=O)O)N(N=C2)C5=CC=C(C=C5)F
  • 化学全称
    (S)-5-((1-(4,4-difluoro-3-(3-fluoro-1H-pyrazol-1-yl)butanoyl)-4-hydroxypiperidin-4-yl)methyl)-1-(4-fluorophenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Turnbull AP, et al. Nature. 2017 Oct 26;550(7677):481-486.
产品手册
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