FT-671 ( FT671;FT 671 )

产品货号. M13072 CAS No. 1959551-26-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

FT-671
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

FT-671 is a novel potent, specific, non-covalent USP7 inhibitor with Kd of 65 nM (USP7 catalytic domain).
产品描述

FT-671 is a novel potent, specific, non-covalent USP7 inhibitor with Kd of 65 nM (USP7 catalytic domain); inhibits USP7 with IC50 values of 52 nM (USP7 CD) and 69 nM (USP7C-term), display good USP7 selectivity in a panel of 38 deubiquitinases (DUBs); destabilizes USP7 substrates including MDM2, increases levels of p53, and results in the transcription of p53 target genes and induces tumour suppressor p21; blocks the proliferation of MM.1S cells (IC50=33 nM), suppresses tumour growth in mice; orally available.
同义词

FT671;FT 671
通路

Proteasome/Ubiquitin
靶点

DUB
受体

DUB
研究领域

Cancer
适应症

——

CAS Number

1959551-26-8
分子量

533.49
分子式

C24H23F4N7O3
纯度

>98% (HPLC)
溶解度

——
SMILES

O=C1C2=C(N=CN1CC3(CCN(CC3)C(C[C@@H](C(F)F)N4N=C(C=C4)F)=O)O)N(N=C2)C5=CC=C(C=C5)F
化学全称

(S)-5-((1-(4,4-difluoro-3-(3-fluoro-1H-pyrazol-1-yl)butanoyl)-4-hydroxypiperidin-4-yl)methyl)-1-(4-fluorophenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one

1. Turnbull AP, et al. Nature. 2017 Oct 26;550(7677):481-486.

计算器

产品手册

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