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MKC-733
CAS No. 194093-42-0
MKC-733 ( MKC733;Pumosetrag;DDP 733 )
产品货号. M13042 CAS No. 194093-42-0
A potent, selective, orally active 5-HT3 receptor agonist with high affinity for canine intestinal smooth muscle 5-HT3 receptors.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 100MG | 获取报价 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称MKC-733
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述A potent, selective, orally active 5-HT3 receptor agonist with high affinity for canine intestinal smooth muscle 5-HT3 receptors.
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产品描述A potent, selective, orally active 5-HT3 receptor agonist with high affinity for canine intestinal smooth muscle 5-HT3 receptors; dose dependently stimulates contraction and basal electrolyte secretion in the isolated guinea pig colon, effects that are antagonized by the selective 5-HT3 antagonist ondansetron, also accelerates gastric emptying in some animal models.Irritable Bowel Syndrome Phase 2 Discontinued
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同义词MKC733;Pumosetrag;DDP 733
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通路Endocrinology/Hormones
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靶点5-HT Receptor
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受体5-HT Receptor
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研究领域Other Indications
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适应症Irritable Bowel Syndrome
化学信息
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CAS Number194093-42-0
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分子量39.84
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分子式C15H18ClN3O2S
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纯度>98% (HPLC)
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溶解度DMSO : 30 mg/mL 88.28 mM
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SMILESO=C(C1=CNC(C=CS2)=C2C1=O)N[C@H]3CN4CCC3CC4.[H]Cl
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化学全称Thieno[3,2-b]pyridine-6-carboxamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4,7-dihydro-7-oxo-, monohydrochloride (9CI)
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Coleman NS, et al. Aliment Pharmacol Ther. 2003 Nov 15;18(10):1039-48.
2. Fujita T, et al.
3. Chetty N, et al. Pharmacology. 2008;81(2):104-9.
4. Choung RS, et al. Neurogastroenterol Motil. 2014 Jan;26(1):13-20.
2. Fujita T, et al.
3. Chetty N, et al. Pharmacology. 2008;81(2):104-9.
4. Choung RS, et al. Neurogastroenterol Motil. 2014 Jan;26(1):13-20.
产品手册
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