021-51111890
购物车（）
sales@molnova.cn
MKC-733
CAS No. 194093-42-0
MKC-733 ( MKC733;Pumosetrag;DDP 733 )
产品货号. M13042 CAS No. 194093-42-0
A potent, selective, orally active 5-HT3 receptor agonist with high affinity for canine intestinal smooth muscle 5-HT3 receptors.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 100MG | 获取报价 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称MKC-733
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述A potent, selective, orally active 5-HT3 receptor agonist with high affinity for canine intestinal smooth muscle 5-HT3 receptors.
-
产品描述A potent, selective, orally active 5-HT3 receptor agonist with high affinity for canine intestinal smooth muscle 5-HT3 receptors; dose dependently stimulates contraction and basal electrolyte secretion in the isolated guinea pig colon, effects that are antagonized by the selective 5-HT3 antagonist ondansetron, also accelerates gastric emptying in some animal models.Irritable Bowel Syndrome Phase 2 Discontinued
-
同义词MKC733;Pumosetrag;DDP 733
-
通路Endocrinology/Hormones
-
靶点5-HT Receptor
-
受体5-HT Receptor
-
研究领域Other Indications
-
适应症Irritable Bowel Syndrome
化学信息
-
CAS Number194093-42-0
-
分子量39.84
-
分子式C15H18ClN3O2S
-
纯度>98% (HPLC)
-
溶解度DMSO : 30 mg/mL 88.28 mM
-
SMILESO=C(C1=CNC(C=CS2)=C2C1=O)N[C@H]3CN4CCC3CC4.[H]Cl
-
化学全称Thieno[3,2-b]pyridine-6-carboxamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4,7-dihydro-7-oxo-, monohydrochloride (9CI)
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Coleman NS, et al. Aliment Pharmacol Ther. 2003 Nov 15;18(10):1039-48.
2. Fujita T, et al.
3. Chetty N, et al. Pharmacology. 2008;81(2):104-9.
4. Choung RS, et al. Neurogastroenterol Motil. 2014 Jan;26(1):13-20.
2. Fujita T, et al.
3. Chetty N, et al. Pharmacology. 2008;81(2):104-9.
4. Choung RS, et al. Neurogastroenterol Motil. 2014 Jan;26(1):13-20.
产品手册
关联产品
-
SB1317
SB1317 is a potent inhibitor of cyclin dependant kinases (CDKs), Janus kinase 2 (JAK2), and Fms-like tyrosine kinase-3 (FLT3).
-
PRX-08066
PRX-08066 is a selective 5-hydroxytryptamine receptor 2B (5-HT2BR, IC50= 3.4 nM) antagonist that induces selective vasodilation of pulmonary arteries.
-
Peptide 401
Peptide 401 is an antimicrobial peptide (AMP) derived from the venom of bees and wasps. Peptide 401 induces mast cell degranulation, activating histamine release from peritoneal mast cells. Additionally, peptide 401 exhibits some anti-inflammatory activity, decreasing paw edema in animal models.
