MK-3281
CAS No. 886041-60-7
MK-3281 ( MK3281 )
产品货号. M16413 CAS No. 886041-60-7
MK-3281 is a potent and orally bioavailable inhibitor of HCV NS5B polymerase with IC50 of 6 nM; MK-3281 is an equally potent inhibitor of gt 1a (EC50=28 nM), 1b BK (EC50=9 nM), and 3a (EC50=37 nM) replicons.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥9477 | 有现货 |
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50MG | ¥19278 | 有现货 |
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100MG | ¥25110 | 有现货 |
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200MG | 获取报价 | 有现货 |
|
500MG | 获取报价 | 有现货 |
|
1G | 获取报价 | 有现货 |
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生物学信息
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产品名称MK-3281
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述MK-3281 is a potent and orally bioavailable inhibitor of HCV NS5B polymerase with IC50 of 6 nM; MK-3281 is an equally potent inhibitor of gt 1a (EC50=28 nM), 1b BK (EC50=9 nM), and 3a (EC50=37 nM) replicons.
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产品描述MK-3281 is a potent and orally bioavailable inhibitor of HCV NS5B polymerase with IC50 of 6 nM; MK-3281 is an equally potent inhibitor of gt 1a (EC50=28 nM), 1b BK (EC50=9 nM), and 3a (EC50=37 nM) replicons, shows 2 orders of magnitude less active on 2a (EC50=2018 nM) and 2b (EC50=1833 nM) replicons; demonstrates consistent decrease in viremia in vivo using the chimeric mouse model of HCV infection.HCV Infection Phase 1 Discontinued
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同义词MK3281
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通路Microbiology/Virology
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靶点HCV
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受体HCV
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研究领域Infection
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适应症HCV Infection
化学信息
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CAS Number886041-60-7
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分子量475.63
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分子式C29H37N3O3
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纯度>98% (HPLC)
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溶解度——
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SMILESO=C(C1=CC2=C(C=C1)C(C3CCCCC3)=C4N2CC(N(CCN(C)C)C)COC5=CC=CC=C45)O
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化学全称(7R)-14-Cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl)amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylic acid
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Narjes F, et al. J Med Chem. 2011 Jan 13;54(1):289-301.
产品手册
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