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首页- Products - Microbiology/Virology - HCV - Faldaprevir

Faldaprevir

CAS No. 801283-95-4

Faldaprevir ( BI 201335;BI201335;BI-201335 )

产品货号. M15999 CAS No. 801283-95-4

A potent, selective noncovalent competitive inhibitor of HCV NS3/4A protease with Ki of 2.6 and 2.0 nM for GT1a and 1b NS3-NS4A protease, respectively.

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ￥7857 有现货
100MG 获取报价 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货
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生物学信息

  • 产品名称
    Faldaprevir
  • 注意事项
    本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
  • 产品简述
    A potent, selective noncovalent competitive inhibitor of HCV NS3/4A protease with Ki of 2.6 and 2.0 nM for GT1a and 1b NS3-NS4A protease, respectively.
  • 产品描述
    A potent, selective noncovalent competitive inhibitor of HCV NS3/4A protease with Ki of 2.6 and 2.0 nM for GT1a and 1b NS3-NS4A protease, respectively; also shows Ki of 2 to 230 nM for HCV GT2 to 6, potently inhibits HCV RNA replication in vitro of 6.5 and 3.1 nM in genotype 1a and 1b replicon assays, respectively; possesses good ADME profile in vitro and pharmacokinetics in vivo.HCV Infection Phase 2 Clinical
  • 同义词
    BI 201335;BI201335;BI-201335
  • 通路
    Microbiology/Virology
  • 靶点
    HCV
  • 受体
    HCV
  • 研究领域
    Infection
  • 适应症
    HCV Infection

化学信息

  • CAS Number
    801283-95-4
  • 分子量
    869.83
  • 分子式
    C40H49BrN6O9S
  • 纯度
    >98% (HPLC)
  • 溶解度
    ——
  • SMILES
    O=C([C@]1(NC([C@H]2N(C([C@@H](NC(OC3CCCC3)=O)C(C)(C)C)=O)C[C@H](OC4=CC(C5=CSC(NC(C(C)C)=O)=N5)=NC6=C(Br)C(OC)=CC=C46)C2)=O)[C@H](C=C)C1)O
  • 化学全称
    (1R,2S)-1-[[(2S,4R)-4-[8-bromo-7-methoxy-2-[2-(2-methylpropanoylamino)-1,3-thiazol-4-yl]quinolin-4-yl]oxy-1-[(2S)-2-(cyclopentyloxycarbonylamino)-3,3-dimethylbutanoyl]pyrrolidine-2-carbonyl]amino]-2 ethenylcyclopropane-1-carboxylic acid

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Llinàs-Brunet M, et al. J Med Chem. 2010 Sep 9;53(17):6466-76.
2. White PW, et al. Antimicrob Agents Chemother. 2010 Nov;54(11):4611-8.
3. Manns MP, et al. J Hepatol. 2011 Jun;54(6):1114-22.
4. Zeuzem S, et al. Gastroenterology. 2011 Dec;141(6):2047-55; quiz e14.
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