MK-0974 ( Telcagepant )

产品货号. M15947 CAS No. 781649-09-0

A potent, selective, orally bioavailable CGRP receptor antagonist with Ki of 0.77 nM.

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
50MG	￥8068	有现货
100MG	￥12879	有现货
200MG	获取报价	有现货
500MG	获取报价	有现货
1G	获取报价	有现货

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生物学信息

产品名称

MK-0974
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

A potent, selective, orally bioavailable CGRP receptor antagonist with Ki of 0.77 nM.
产品描述

A potent, selective, orally bioavailable CGRP receptor antagonist with Ki of 0.77 nM; shows >10,000-fold selectivity in a panel of assays representing over 160 receptors, transporters, and enzymes; inhibits CGRP-stimulated cAMP production in E10 cells with IC50 of 2.2 nM; inhibits the capsaicin-induced increase in dermal blood flow in monkey models.Migraine Phase 3 Discontinued
同义词

Telcagepant
通路

GPCR/G Protein
靶点

CGRP Receptor
受体

CGRP Receptor
研究领域

Neurological Disease
适应症

Migraine

化学信息

CAS Number

781649-09-0
分子量

566.52
分子式

C26H27F5N6O3
纯度

>98% (HPLC)
溶解度

10 mM in DMSO
SMILES

O=C(N1CCC(N(C2=CC=CN=C2N3)C3=O)CC1)N[C@H]4C(N(CC(F)(F)F)C[C@H](C5=CC=CC(F)=C5F)CC4)=O
化学全称

1-Piperidinecarboxamide, N-[(3R,6S)-6-(2,3-difluorophenyl)hexahydro-2-oxo-1-(2,2,2-trifluoroethyl)-1H-azepin-3-yl]-4-(2,3-dihydro-2-oxo-1H-imidazo[4,5-b]pyridin-1-yl)-

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1. Paone DV, et al. J Med Chem. 2007 Nov 15;50(23):5564-7.
2. Salvatore CA, et al. J Pharmacol Exp Ther. 2008 Feb;324(2):416-21.
3. Sinclair SR, et al. Br J Clin Pharmacol. 2010 Jan;69(1):15-22.

计算器

浓度计算器

摩尔计算器

分子量计算器

产品手册

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