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MK-0974
CAS No. 781649-09-0
MK-0974 ( Telcagepant )
产品货号. M15947 CAS No. 781649-09-0
A potent, selective, orally bioavailable CGRP receptor antagonist with Ki of 0.77 nM.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 50MG | ￥8068 | 有现货 |
|
| 100MG | ￥12879 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称MK-0974
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述A potent, selective, orally bioavailable CGRP receptor antagonist with Ki of 0.77 nM.
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产品描述A potent, selective, orally bioavailable CGRP receptor antagonist with Ki of 0.77 nM; shows >10,000-fold selectivity in a panel of assays representing over 160 receptors, transporters, and enzymes; inhibits CGRP-stimulated cAMP production in E10 cells with IC50 of 2.2 nM; inhibits the capsaicin-induced increase in dermal blood flow in monkey models.Migraine Phase 3 Discontinued
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同义词Telcagepant
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通路GPCR/G Protein
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靶点CGRP Receptor
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受体CGRP Receptor
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研究领域Neurological Disease
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适应症Migraine
化学信息
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CAS Number781649-09-0
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分子量566.52
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分子式C26H27F5N6O3
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纯度>98% (HPLC)
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溶解度10 mM in DMSO
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SMILESO=C(N1CCC(N(C2=CC=CN=C2N3)C3=O)CC1)N[C@H]4C(N(CC(F)(F)F)C[C@H](C5=CC=CC(F)=C5F)CC4)=O
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化学全称1-Piperidinecarboxamide, N-[(3R,6S)-6-(2,3-difluorophenyl)hexahydro-2-oxo-1-(2,2,2-trifluoroethyl)-1H-azepin-3-yl]-4-(2,3-dihydro-2-oxo-1H-imidazo[4,5-b]pyridin-1-yl)-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Paone DV, et al. J Med Chem. 2007 Nov 15;50(23):5564-7.
2. Salvatore CA, et al. J Pharmacol Exp Ther. 2008 Feb;324(2):416-21.
3. Sinclair SR, et al. Br J Clin Pharmacol. 2010 Jan;69(1):15-22.
2. Salvatore CA, et al. J Pharmacol Exp Ther. 2008 Feb;324(2):416-21.
3. Sinclair SR, et al. Br J Clin Pharmacol. 2010 Jan;69(1):15-22.
产品手册
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