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MK-8825
CAS No. 1380887-60-4
MK-8825 ( MK8825 )
产品货号. M11576 CAS No. 1380887-60-4
MK-8825 is a highly potent, selective, orally bioavailable CGRP receptor antagonist with Ki of 17 nM for rat CGRP.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥15957 | 有现货 |
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| 50MG | ￥32238 | 有现货 |
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| 100MG | ￥44550 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称MK-8825
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述MK-8825 is a highly potent, selective, orally bioavailable CGRP receptor antagonist with Ki of 17 nM for rat CGRP.
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产品描述MK-8825 is a highly potent, selective, orally bioavailable CGRP receptor antagonist with Ki of 17 nM for rat CGRP; blocks hCGRP-stimulated cAMP responses in HEK293 cells stably expressing the human CGRP receptor with IC50 of 0.23 nM; possesses significantly improved in vivo potency in rat pharmacodynamic models.Migraine Phase 1 Clinical
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同义词MK8825
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通路GPCR/G Protein
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靶点CGRP Receptor
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受体CGRP Receptor
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研究领域Neurological Disease
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适应症Migraine
化学信息
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CAS Number1380887-60-4
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分子量572.62
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分子式C31H30F2N6O3
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纯度>98% (HPLC)
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溶解度——
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SMILESCC1(CNC2(CCCC2)C(=O)N1CC(=O)NC3=CC4=C(CC5(C4)C6=C(NC5=O)N=CC=C6)N=C3)C7=CC(=CC(=C7)F)F
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化学全称2-[(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4.5]dec-9-yl]-N-[(6S)-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridin]-3-yl]acetamide
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Bell IM, et al. Bioorg Med Chem Lett. 2012 Jun 15;22(12):3941-5.
2. Michot B, et al. Eur J Pain. 2015 Feb;19(2):281-90.
3. Romero-Reyes M, et al. Exp Neurol. 2015 Sep;271:95-103.
4. Feistel S, et al. J Headache Pain. 2013 Nov 20;14:93.
2. Michot B, et al. Eur J Pain. 2015 Feb;19(2):281-90.
3. Romero-Reyes M, et al. Exp Neurol. 2015 Sep;271:95-103.
4. Feistel S, et al. J Headache Pain. 2013 Nov 20;14:93.
产品手册
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