021-51111890
购物车（）
sales@molnova.cn
MK-8825
CAS No. 1380887-60-4
MK-8825 ( MK8825 )
产品货号. M11576 CAS No. 1380887-60-4
MK-8825 is a highly potent, selective, orally bioavailable CGRP receptor antagonist with Ki of 17 nM for rat CGRP.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥15957 | 有现货 |
|
| 50MG | ￥32238 | 有现货 |
|
| 100MG | ￥44550 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称MK-8825
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述MK-8825 is a highly potent, selective, orally bioavailable CGRP receptor antagonist with Ki of 17 nM for rat CGRP.
-
产品描述MK-8825 is a highly potent, selective, orally bioavailable CGRP receptor antagonist with Ki of 17 nM for rat CGRP; blocks hCGRP-stimulated cAMP responses in HEK293 cells stably expressing the human CGRP receptor with IC50 of 0.23 nM; possesses significantly improved in vivo potency in rat pharmacodynamic models.Migraine Phase 1 Clinical
-
同义词MK8825
-
通路GPCR/G Protein
-
靶点CGRP Receptor
-
受体CGRP Receptor
-
研究领域Neurological Disease
-
适应症Migraine
化学信息
-
CAS Number1380887-60-4
-
分子量572.62
-
分子式C31H30F2N6O3
-
纯度>98% (HPLC)
-
溶解度——
-
SMILESCC1(CNC2(CCCC2)C(=O)N1CC(=O)NC3=CC4=C(CC5(C4)C6=C(NC5=O)N=CC=C6)N=C3)C7=CC(=CC(=C7)F)F
-
化学全称2-[(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4.5]dec-9-yl]-N-[(6S)-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridin]-3-yl]acetamide
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Bell IM, et al. Bioorg Med Chem Lett. 2012 Jun 15;22(12):3941-5.
2. Michot B, et al. Eur J Pain. 2015 Feb;19(2):281-90.
3. Romero-Reyes M, et al. Exp Neurol. 2015 Sep;271:95-103.
4. Feistel S, et al. J Headache Pain. 2013 Nov 20;14:93.
2. Michot B, et al. Eur J Pain. 2015 Feb;19(2):281-90.
3. Romero-Reyes M, et al. Exp Neurol. 2015 Sep;271:95-103.
4. Feistel S, et al. J Headache Pain. 2013 Nov 20;14:93.
产品手册
关联产品
-
α-CGRP (human)
Endogenous calcitonin gene-related peptide receptor (CGRP) agonist.
-
MK-8825
MK-8825 is a highly potent, selective, orally bioavailable CGRP receptor antagonist with Ki of 17 nM for rat CGRP.
-
Olcegepant
The first small molecule selective CGRP antagonist with Ki of 14.4 nM for hCGRP.
