Olcegepant ( BIBN-4096;BIBN-4096BS;BIBN4096BS )

产品货号. M13181 CAS No. 204697-65-4

The first small molecule selective CGRP antagonist with Ki of 14.4 nM for hCGRP.

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
2MG	￥381	有现货
5MG	￥786	有现货
100MG	获取报价	有现货
200MG	获取报价	有现货
500MG	获取报价	有现货
1G	获取报价	有现货

拼团产品询价大包装询价加入购物车

生物学信息

产品名称

Olcegepant
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

The first small molecule selective CGRP antagonist with Ki of 14.4 nM for hCGRP.
产品描述

The first small molecule selective CGRP antagonist with Ki of 14.4 nM for hCGRP; inhibits the effects of CGRP, released by stimulation of the trigeminal ganglion, on facial blood flow in marmoset monkeys (1-30mg/kg, i.v.).
同义词

BIBN-4096;BIBN-4096BS;BIBN4096BS
通路

GPCR/G Protein
靶点

CGRP Receptor
受体

CGRP Receptor
研究领域

Neurological Disease
适应症

——

化学信息

CAS Number

204697-65-4
分子量

869.65
分子式

C38H47Br2N9O5
纯度

>98% (HPLC)
溶解度

DMSO: ≥ 50 mg/mL
SMILES

O=C(N1CCC(N2C(NC3=C(C=CC=C3)C2)=O)CC1)N[C@H](CC4=CC(Br)=C(O)C(Br)=C4)C(N[C@H](C(N5CCN(C6=CC=NC=C6)CC5)=O)CCCCN)=O
化学全称

Piperazine, 1-[3,5-dibromo-N-[[4-(1,4-dihydro-2-oxo-3(2H)-quinazolinyl)-1-piperidinyl]carbonyl]-D-tyrosyl-L-lysyl]-4-(4-pyridinyl)-

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1. Doods H, et al. Br J Pharmacol. 2000 Feb;129(3):420-3.
2. Powell KJ, et al. Br J Pharmacol. 2000 Nov;131(5):875-84.
3. Edvinsson L, et al. Eur J Pharmacol. 2002 Jan 2;434(1-2):49-53.

计算器

浓度计算器

摩尔计算器

分子量计算器

产品手册

关联产品

MK-3207

A highly potent, selective CGRP receptor antagonist with Ki of 21 pM in in vitro binding assay and IC50 of 0.12 nM in cell-based functional assay.
Calcitonin (human)

Endogenous calcitonin receptor agonist. Lowers systemic blood calcium levels and inhibits bone resorption.
Olcegepant (hydrochl...

The first small molecule selective CGRP antagonist with Ki of 14.4 nM for hCGRP.

Product			Quantity Required*
Name *			E-mail Address *
Organization *			Phone Number
Remarks