021-51111890
购物车（）
sales@molnova.cn
MK-3207
CAS No. 957118-49-9
MK-3207 ( MK3207;MK 3207 )
产品货号. M16837 CAS No. 957118-49-9
A highly potent, selective CGRP receptor antagonist with Ki of 21 pM in in vitro binding assay and IC50 of 0.12 nM in cell-based functional assay.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 10MG | ￥2911 | 有现货 |
|
| 100MG | 获取报价 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称MK-3207
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述A highly potent, selective CGRP receptor antagonist with Ki of 21 pM in in vitro binding assay and IC50 of 0.12 nM in cell-based functional assay.
-
产品描述A highly potent, selective CGRP receptor antagonist with Ki of 21 pM in in vitro binding assay and IC50 of 0.12 nM in cell-based functional assay; displays >50000-fold selectivity in a panel of 160 enzymes, receptors, channels, and 65-fold more potent than telcagepant; orally bioavailable.
-
同义词MK3207;MK 3207
-
通路GPCR/G Protein
-
靶点CGRP Receptor
-
受体CGRP Receptor
-
研究领域Neurological Disease
-
适应症——
化学信息
-
CAS Number957118-49-9
-
分子量557.59
-
分子式C31H29F2N5O3
-
纯度>98% (HPLC)
-
溶解度10 mM in DMSO
-
SMILESC1CCC2(C1)C(=O)N(C(CN2)C3=CC(=CC(=C3)F)F)CC(=O)NC4=CC5=C(CC6(C5)C7=C(NC6=O)N=CC=C7)C=C4
-
化学全称6,9-Diazaspiro[4.5]decane-9-acetamide, 8-(3,5-difluorophenyl)-10-oxo-N-[(2R)-1,1',2',3-tetrahydro-2'-oxospiro[2H-indene-2,3'-[3H]pyrrolo[2,3-b]pyridin]-5-yl]-, (8R)-
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Bell IM, et al. ACS Med Chem Lett. 2010 Jan 12;1(1):24-9.
2. Salvatore CA, et al. J Pharmacol Exp Ther. 2010 Apr;333(1):152-60.
3. Li CC, et al. Br J Clin Pharmacol. 2015 May;79(5):831-7.
2. Salvatore CA, et al. J Pharmacol Exp Ther. 2010 Apr;333(1):152-60.
3. Li CC, et al. Br J Clin Pharmacol. 2015 May;79(5):831-7.
产品手册
关联产品
-
Calcitonin (human)
Endogenous calcitonin receptor agonist. Lowers systemic blood calcium levels and inhibits bone resorption.
-
Adrenomedullin (11-5...
Adrenomedullin 11-50 rat is a peptide fragment of adrenomedullin that possesses systemic vasodilator activity at the level of calcitonin gene-related peptide-1 (CGRP1) receptor activation. Adrenomedullin and its peptide may be used in bone growth studies.
-
PHM 27 (human)
Endogenous peptide product of human prepro-VIP and analog of porcine PHI-27; potent agonist for the human calcitonin receptor (EC50 = 11 nM). Transgenic mice expressing the human VIP/PHM 27 gene in pancreatic β-islets display enhanced glucose-induced insulin secretion.
