MAZ51

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

MAZ51 is a VEGFR-3 (Flt-4) tyrosine kinase inhibitor.?MAZ51 is able to block the proliferation of VEGFR-3-expressing human endothelial cells and is less potently able to induce their apoptosis.?

MAZ51 is a VEGFR-3 (Flt-4) tyrosine kinase inhibitor.?MAZ51 is able to block the proliferation of VEGFR-3-expressing human endothelial cells and is less potently able to induce their apoptosis.?MAZ51 also inhibits the proliferation and induces the apoptosis of a variety of non-VEGFR-3-expressing tumor cell lines.In vivo, MAZ51 significantly inhibits the growth of rat mammary carcinomas.?These data establish MAZ51 as a compound with antitumor properties that inhibits tumor growth directly and also indirectly by interfering with tumor-host interactions.

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Angiogenesis

VEGFR

VEGFR3

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163655-37-6

314.38

C21H18N2O

>98% (HPLC)

DMSO:3.33 mg/ml(10.59 mM; Need ultrasonic)

CN(C)c1ccc(C=C2C(=O)Nc3ccccc23)c2ccccc12

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(-20℃)

With Ice Pack

≥ 2 years