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Fruquintinib
CAS No. 1194506-26-7
Fruquintinib ( HMPL-013 )
产品货号. M10681 CAS No. 1194506-26-7
A potent and highly selective small molecule inhibitor of VEGFR1/2/3 with IC50 of 33/3/5/0.5 nM, respectively.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥243 | 有现货 |
|
| 5MG | ￥389 | 有现货 |
|
| 10MG | ￥624 | 有现货 |
|
| 25MG | ￥964 | 有现货 |
|
| 50MG | ￥1215 | 有现货 |
|
| 100MG | ￥2130 | 有现货 |
|
| 500MG | ￥5289 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Fruquintinib
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述A potent and highly selective small molecule inhibitor of VEGFR1/2/3 with IC50 of 33/3/5/0.5 nM, respectively.
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产品描述A potent and highly selective small molecule inhibitor of VEGFR1/2/3 with IC50 of 33/3/5/0.5 nM, respectively; weakly inhibits RET, FGFR-1 and c-kit kinases; demonstrates potent inhibition on VEGF-A dependent KDR phosphorylation in HEK293-KDR cells and VEGF-A induced proliferation in primary HUVECs with IC50 of 0.6 nM and 1.7 nM, respectively; suppresses tumor growth inhibition in a panel of tumor xenograft and patient derive xenograft models in mouse; orally active.Colon Cancer Phase 3 Clinical
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同义词HMPL-013
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通路Angiogenesis
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靶点VEGFR
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受体VEGFR
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研究领域Cancer
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适应症Colon Cancer
化学信息
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CAS Number1194506-26-7
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分子量393.39
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分子式C21H19N3O5
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纯度>98% (HPLC)
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溶解度DMSO: 7.75 mg/mL
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SMILESO=C(C1=C(C)OC2=CC(OC3=C4C=C(OC)C(OC)=CC4=NC=N3)=CC=C12)NC
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化学全称3-Benzofurancarboxamide, 6-[(6,7-dimethoxy-4-quinazolinyl)oxy]-N,2-dimethyl-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Sun Q, et al. Cancer Biol Ther. 2014;15(12):1635-45.
2. Gu Y, et al. Cancer Chemother Pharmacol. 2014 Jul;74(1):95-115.
3. Cao J, et al. Cancer Chemother Pharmacol. 2016 Aug;78(2):259-69.
2. Gu Y, et al. Cancer Chemother Pharmacol. 2014 Jul;74(1):95-115.
3. Cao J, et al. Cancer Chemother Pharmacol. 2016 Aug;78(2):259-69.
产品手册
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