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Angoline hydrochloride
CAS No. 1071676-04-4
Angoline hydrochloride ( —— )
产品货号. M36640 CAS No. 1071676-04-4
Angoline hydrochloride 是一种有效的、选择性的 IL6/STAT3 信号通路抑制剂，IC50 为 11.56 μM。Angoline hydrochloride 抑制 STAT3 磷酸化及其靶基因表达，并抑制癌细胞增殖。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥645 | 有现货 |
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| 10MG | ￥938 | 有现货 |
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| 25MG | ￥1716 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Angoline hydrochloride
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Angoline hydrochloride 是一种有效的、选择性的 IL6/STAT3 信号通路抑制剂，IC50 为 11.56 μM。Angoline hydrochloride 抑制 STAT3 磷酸化及其靶基因表达，并抑制癌细胞增殖。
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产品描述Angoline hydrochloride is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC50 of 11.56 μM. Angoline hydrochloride inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation.
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体外实验Angoline hydrochloride (0-100 μM; 1 h) inhibits STAT3, STAT1 and NF-κB signaling pathways with IC50 values of 11.56, ＞100 and ＞100 μM, respectively.Angoline hydrochloride (0-100 μM; 2 h) affects phosphorylation of STAT3.Angoline hydrochloride (0-100 μM; 72 h) inhibits MDA-MB-231, H4 and HepG2 cells proliferation.Western Blot Analysis Cell Line:HepG2/STAT3 cell lines Concentration:0, 1, 10, 30 and 100 μM Incubation Time:2 hours Result:Inhibited IL-6-induced phosphorylation of STAT3 in HepG2/STAT3 cells.Western Blot Analysis Cell Line:MDA-MB-231, H4 and HepG2 cell lines Concentration:0-100 μM Incubation Time:72 hours Result: Inhibited proliferation of MDA-MB-231, H4 and HepG2 cells with IC50 values of 3.32, 4.72 and 3.14 μM, respectively.
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体内实验——
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同义词——
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通路Apoptosis
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靶点IL Receptor
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受体IL Receptor | STAT
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研究领域——
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适应症——
化学信息
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CAS Number1071676-04-4
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分子量415.87
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分子式C22H22ClNO5
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纯度>98% (HPLC)
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溶解度——
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SMILESCl.O(C=1C=CC=2C3=CC=C4C=C5OCOC5=CC4=C3N(C)C(OC)C2C1OC)C
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Jiawei Liu, et al. Angoline: a selective IL-6/STAT3 signaling pathway inhibitor isolated from Zanthoxylum nitidum. Phytomedicine. Jul-Aug 2014;21(8-9):1088-91.?
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