Taurodeoxycholic acid

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Taurodeoxycholic acid 是一种胆汁酸，可稳定线粒体膜，减少自由基形成。Taurodeoxycholic acid 通过阻断钙介导的凋亡通路以及 Caspase-12 激活来抑制凋亡 (apoptosis)。Taurodeoxycholic acid 对 3-硝基丙酸诱导或稳定遗传的亨廷顿舞蹈病 (HD) 小鼠模型具有神经保护作用。

Taurodeoxycholic acid, a bile acid, stabilizes the mitochondrial membrane, decreases free radical formation. Taurodeoxycholic acid inhibits apoptosis by blocking a calcium-mediated apoptotic pathway as well as caspase-12 activation. Taurodeoxycholic acid exhibits neuroprotective effect in 3-nitropropionic acid induced mouse model or genetic mouse model of Huntington's disease (HD).

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Animal Model:Huntington's disease model in mouseDosage:50 mg/kg Administration:Intraperitoneal injection; once daliy for 34 d, injected 3-NP at 6 hr after Taurodeoxycholic acid treatment Result:Reduced striatal atrophy, decreased striatal apoptosis, as well as fewer and smaller size ubiquitinated neuronal intranuclear huntingtin inclusions.Significantly improved locomotor and sensorimotor deficits.

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Apoptosis

Apoptosis

Apoptosis | Calcium Channel | Caspase

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516-50-7

499.7

C26H45NO6S

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 100 mg/mL (200.12 mM; 超声助溶 )

C[C@@]12[C@]([C@]3([C@@]([C@]4(C)[C@](CC3)(C[C@H](O)CC4)[H])(C[C@@H]1O)[H])[H])(CC[C@@]2([C@@H](CCC(NCCS(=O)(=O)O)=O)C)[H])[H]

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(-20℃)

With Ice Pack

≥ 2 years