KW-2450 free base ( —— )

产品货号. M36254 CAS No. 904899-25-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

KW-2450 free base
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

KW-2450 free base is an orally bioavailable inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (IR) tyrosine kinases with potential antineoplastic activity. IGF-1R/IR inhibitor KW-2450 free base selectively binds to and inhibits the activities of IGF-1R and IR, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. IGF-R1 and IR tyrosine kinases, overexpressed in a variety of human cancers, play significant roles in the stimulation of cellular proliferation, oncogenic transformation, and suppression of apoptosis.
产品描述

KW-2450 free base is an orally bioavailable inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (IR) tyrosine kinases with potential antineoplastic activity. IGF-1R/IR inhibitor KW-2450 free base selectively binds to and inhibits the activities of IGF-1R and IR, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. IGF-R1 and IR tyrosine kinases, overexpressed in a variety of human cancers, play significant roles in the stimulation of cellular proliferation, oncogenic transformation, and suppression of apoptosis.
体外实验

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体内实验

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同义词

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通路

Angiogenesis
靶点

IGF-1R
受体

IGF-1R
研究领域

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适应症

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CAS Number

904899-25-8
分子量

515.63
分子式

C28H29N5O3S
纯度

>98% (HPLC)
溶解度

——
SMILES

C(=C/C1=C(NC(=O)C=2SC=CC2C)C=C(CN3CCN(C(CO)=O)CC3)C=C1)\C=4C=5C(NN4)=CC=CC5
化学全称

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计算器

产品手册

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