AZ7550 trimesylate salt

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

AZ7550 Mesylate 是 AZD9291 的一种活性代谢物，AZ7550 抑制 IGF1R 活性，IC50 为 1.6 μM。

AZ7550 Mesylate is an active metabolite of AZD9291 and inhibits the activity of IGF1R with an IC50 of 1.6 μM.

AZ7550 (Compound 28) appeares to offer a broadly similar potency and selectivity profile to the parent compound AZD9291. AZ7550 inhibits double mutant (DM) cell line H1975, activating mutant (AM) cell line PC9, and wild type (WT) cell line LoVo with IC50s of 45, 26, and 786 nM, respectively. AZ7550 inhibits DM antiproliferative cell line H1975, AM antiproliferative cell line PC9, and WT antiproliferative cell line Calu3 with GI50s of 19, 15, and 537 nM, respectively.

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Angiogenesis

IGF-1R

IGF-1R

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2319837-99-3

773.9

C30H43N7O11S3

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 25 mg/mL (32.30 mM; 超声助溶 )

O=C(NC1=CC(NC2=NC(C3=CN(C)C4=C3C=CC=C4)=CC=N2)=C(C=C1N(CCNC)C)OC)C=C.O=S(O)(C)=O.O=S(O)(C)=O.O=S(O)(C)=O

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(-20℃)

With Ice Pack

≥ 2 years