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AZ7550 trimesylate salt
CAS No. 2319837-99-3
AZ7550 trimesylate salt ( —— )
产品货号. M33203 CAS No. 2319837-99-3
AZ7550 Mesylate 是 AZD9291 的一种活性代谢物，AZ7550 抑制 IGF1R 活性，IC50 为 1.6 μM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称AZ7550 trimesylate salt
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述AZ7550 Mesylate 是 AZD9291 的一种活性代谢物，AZ7550 抑制 IGF1R 活性，IC50 为 1.6 μM。
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产品描述AZ7550 Mesylate is an active metabolite of AZD9291 and inhibits the activity of IGF1R with an IC50 of 1.6 μM.
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体外实验AZ7550 (Compound 28) appeares to offer a broadly similar potency and selectivity profile to the parent compound AZD9291. AZ7550 inhibits double mutant (DM) cell line H1975, activating mutant (AM) cell line PC9, and wild type (WT) cell line LoVo with IC50s of 45, 26, and 786 nM, respectively. AZ7550 inhibits DM antiproliferative cell line H1975, AM antiproliferative cell line PC9, and WT antiproliferative cell line Calu3 with GI50s of 19, 15, and 537 nM, respectively.
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体内实验——
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同义词——
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通路Angiogenesis
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靶点IGF-1R
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受体IGF-1R
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研究领域——
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适应症——
化学信息
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CAS Number2319837-99-3
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分子量773.9
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分子式C30H43N7O11S3
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO 中的溶解度 : 25 mg/mL (32.30 mM; 超声助溶 )
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SMILESO=C(NC1=CC(NC2=NC(C3=CN(C)C4=C3C=CC=C4)=CC=N2)=C(C=C1N(CCNC)C)OC)C=C.O=S(O)(C)=O.O=S(O)(C)=O.O=S(O)(C)=O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Finlay MR, et al. Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor. J Med Chem. 2014 Oct 23;57(20):8249-67.?
