Tyrphostin AG 538
CAS No. 133550-18-2
Tyrphostin AG 538 ( —— )
产品货号. M35935 CAS No. 133550-18-2
AG 538 是一种有效的 IGF-1 受体激酶竞争性抑制剂,IC50 为 400 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ¥938 | 有现货 |
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| 5MG | ¥1644 | 有现货 |
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| 10MG | ¥2461 | 有现货 |
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| 25MG | ¥4259 | 有现货 |
|
| 50MG | ¥5933 | 有现货 |
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| 100MG | ¥7731 | 有现货 |
|
| 500MG | ¥15480 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Tyrphostin AG 538
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述AG 538 是一种有效的 IGF-1 受体激酶竞争性抑制剂,IC50 为 400 nM。
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产品描述AG 538 is a potent, competitive inhibitor of IGF-1 receptor kinase, with an IC50 of 400 nM.
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体外实验——
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体内实验——
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同义词——
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通路Angiogenesis
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靶点IGF-1R
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受体IGF-1R
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研究领域——
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适应症——
化学信息
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CAS Number133550-18-2
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分子量297.26
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分子式C16H11NO5
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纯度>98% (HPLC)
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溶解度——
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SMILESC(/C(=C/C1=CC(O)=C(O)C=C1)/C#N)(=O)C2=CC(O)=C(O)C=C2
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
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Cys-Gly
L-半胱氨酰甘氨酸是一种重要的生物学化合物,因为它是在 γ-谷氨酰循环过程中形成的。
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Protonstatin-1
Protonstatin-1 is used as a hypoglycemic agent and as a compound for the treatment of Alzheimer's disease, inhibits IGFIR kinase activity and can be used in cancer research.
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KW-2450 free base
KW-2450 free base is an orally bioavailable inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (IR) tyrosine kinases with potential antineoplastic activity. IGF-1R/IR inhibitor KW-2450 free base selectively binds to and inhibits the activities of IGF-1R and IR, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. IGF-R1 and IR tyrosine kinases, overexpressed in a variety of human cancers, play significant roles in the stimulation of cellular proliferation, oncogenic transformation, and suppression of apoptosis.
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