NT157

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

NT157是一种靶向IRS蛋白的小分子酪氨酸磷酸化抑制剂，有可能抑制TME癌细胞和基质细胞中的IGF-1R和STAT3信号通路，导致癌细胞存活率降低。

NT157 is a small molecule tyrphostin targeting IRS protein and has the potential to inhibit IGF-1R and STAT3 signaling pathways in TME cancer cells and stromal cells, resulting in decreased cancer cell survival.(In Vitro):NT157 treatment resulted in dose-dependent inhibition of IGF1R activation, suppression of IRS protein expression, inhibition of IGF1-induced AKT activation, but increased ERK activation in NT157-treated cells in vitro.(In Vivo):NT157 suppressed androgen-responsive growth, delayed CRPC progression of LNCaP xenografts, and suppressed PC3 tumor growth alone and in combination with docetaxel.

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Angiogenesis

IGF-1R

gp120/CD4|HIV|PKC

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1384426-12-3

412.25

C16H14BrNO5S

>98% (HPLC)

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Oc1cc(CNC(=S)\C=C\c2cc(O)c(O)c(Br)c2)cc(O)c1O

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(-20℃)

With Ice Pack

≥ 2 years