CWI1-2

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

CWI1-2 是一种 IGF2BP2 抑制剂，结合 IGF2BP2 并抑制其与 m6A 修饰的靶转录物的相互作用，可诱导细胞凋亡 (apoptosis)和分化，显示出良好的抗白血病作用。

CWI1-2 is an IGF2BP2 inhibitor that binds IGF2BP2 and inhibits its interaction with m6A-modified target transcripts, induces apoptosis and differentiation, and shows promising anti-leukemic effects.

Apoptosis AnalysisCell Line:MonoMac6, MOLM13Concentration:0-1 μM Incubation Time:24 h Result:Induced significant cell differentiation and apoptosis in a concentration-dependent manner in IGF2BP2-high cells but not in IGF2BP2-low cells. Reduced Gln uptake and impaired mitochondrial function, resulting in reduced ATP production in AML cells. Significantly inhibited the colony-forming ability of MA9-induced leukemic mouse blasts and greatly impairs the self-renewal of LSC/LIC.

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Apoptosis

Apoptosis

Apoptosis

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2408590-36-1

519.77

C22H17Cl3N6O3

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 100 mg/mL (192.39 mM; 超声助溶 )

ClC1=CC=C(O)C(C=NN=C(NN=CC2=CC(Cl)=CC=C2O)NN=CC3=CC(Cl)=CC=C3O)=C1

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(-20℃)

With Ice Pack

≥ 2 years