Snail/HDAC-IN-1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Snail/HDAC-IN-1是一种有效的 Snail/HDAC 双靶点抑制剂。Snail/HDAC-IN-1 对 HDAC1 有较强的抑制活性，IC50 为0.405 μM，对 Snail 有较强的抑制作用，Kd 为 0.18μM。Snail/HDAC-IN-1 增加 HCT-116 细胞中的组蛋白 H4 乙酰化，并降低 Snail 蛋白的表达，从而诱导细胞凋亡 (apoptosis)。

Snail/HDAC-IN-1 is a potent Snail/HDAC dual target inhibitor. Snail/HDAC-IN-1 displays potent inhibitory activity against HDAC1 with an IC50 of 0.405 μM and potent inhibition against Snail with a Kd of 0.18 μM. Snail/HDAC-IN-1 increases histone H4 acetylation in HCT-116 cells and decreases the expression of Snail protein to induce cell apoptosis.

Snail/HDAC-IN-1 (compound 9n) shows antiproliferative activity in HCT-116 cell lines with an IC50 of 0.0751 μM. Snail/HDAC-IN-1 shows a good inhibitory effect on NCI–H522 (GI50=0.0488 μM), MDA-MB-435 (GI50=0.0361 μM), and MCF7 (GI50=0.0518 μM).

——

——

Apoptosis

Apoptosis

Apoptosis | Antifungal

——

——

2415281-52-4

488.54

C24H21FN8OS

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 125 mg/mL (255.86 mM; 超声助溶 (<60°C)

O=C(NC1=CC=C(F)C=C1N)C2=CC=C(C=C2)CSC=3N=C(NC4=NNC(=C4)C)C5=CC=CN5N3

——

(-20℃)

With Ice Pack

≥ 2 years