Anticancer agent 43

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Anticancer Agent 43 是一种有效的抗癌剂。Anticancer Agent 43 通过 caspase 3， PARP1，Bax 蛋白依赖性途径诱导凋亡 (apoptosis)。Anticancer Agent 43 能够诱导 DNA 损伤。

Anticancer Agent 43 is a potent anticancer agent. Anticancer Agent 43 induces apoptosis by caspase 3, PARP1, and Bax dependent mechanisms. Anticancer Agent 43 induces DNA damage.

Anticancer agent 43 (compound 3a) shows selectivity toward human tumor cells (SI50=28.94).Anticancer agent 43 (45 μM, 24 h) induces apoptosis via caspase 3, PARP1 and Bax dependent pathways in HepG2 cells.Anticancer agent 43 (45 μM, 24 h) shows no effect on the transition of G1/S phases in HepG2 cells.Anticancer agent 43 (0.7, 45, 55 μM) induces DNA damage in HCT116 cells (Tail DNA=16.1%, OTM=3.7), MCF-7 cells, HepG2 cells (Tail DNA=26.2%, OTM=13.2), Balb/c 3T3 cells (Tail DNA = 8.4%, OTM = 3.5)..Cell Cytotoxicity Assay Cell Line:HepG2, MCF-7, HCT116, HeLa, A549, WM793, THP-1, HaCaT, Balb/c3T3 cells Concentration:0, 1, 10, 100 μM Incubation Time:72 h Result:Showed cytotoxic action with GI50s of 12.1, 0.7, 0.8, 49.3, 9.7 μM for for HepG2, MCF-7, HCT116, HeLa, A549 cells, low toxicity towards WM793, THP-1, HaCaT, Balb/c 3T3 cells with GI50s of 80.4, 62.4,98.3,40.8 μM , respectively.Apoptosis Analysis Cell Line:HepG2 cells Concentration:45 μM Incubation Time:24 h Result:Induced apoptosis in HepG2 cells via caspase 3, PARP1 and Bax dependent pathways.Western Blot Analysis Cell Line:HCT116, MCF-7 cells Concentration:0.7 μM Incubation Time:24 h Result:Decreased the expression of Cdk2 protein in HCT116 and MCF-7 cells.Cell Cycle Analysis Cell Line:HepG2 cells Concentration:45 μM Incubation Time:24 h Result:Showed no effect on the transition of G1/S phases in HepG2 cells.

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Apoptosis

Apoptosis

Apoptosis

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2470015-35-9

336.36

C14H9FN2O3S2

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 125 mg/mL (371.63 mM; 超声助溶 )

C(C=1C=2C(NC1C(OC)=O)=CC=C(F)C2)=C3C(=O)NC(=S)S3

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(-20℃)

With Ice Pack

≥ 2 years