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CX717
CAS No. 867276-98-0
CX717 ( —— )
产品货号. M35376 CAS No. 867276-98-0
CX 717 是AMPA 受体的正变构调节剂。具有抗抑郁样作用。可用于成人注意力缺陷多动障碍（ADHD）的研究。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥227 | 有现货 |
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| 10MG | ￥378 | 有现货 |
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| 25MG | ￥742 | 有现货 |
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| 50MG | ￥1097 | 有现货 |
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| 100MG | ￥1791 | 有现货 |
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| 200MG | ￥2367 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称CX717
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述CX 717 是AMPA 受体的正变构调节剂。具有抗抑郁样作用。可用于成人注意力缺陷多动障碍（ADHD）的研究。
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产品描述CX 717 is a positive allosteric modulator of AMPA receptor. Antidepressant-like effect. CX 717 can be used for the research of adult attention deficit hyperactivity disorder (ADHD).
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体外实验——
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体内实验CX 717 (CX717; 20 mg/kg) has a rapid (30 min) but short-lasting (up to 24 h) antidepressantlike effect in the forced swim test.CX 717 also produces a rapid (up to 1 h) increase of brain-derived neurotrophic factor (BDNF) and a more sustained (up to 6 h) increase of p11. Intra-cortical infusion of CX 717 (85 mM) increases the efflux of noradrenaline, dopamine, and serotonin, but not glutamate.Animal Model:Male Sprague-Dawley rats weighing 280-350 g Dosage:20 mg/kg (administered at 1 mL/kg) Administration:Intraperitoneal (i.p.) injection Result:Evoked antidepressant-like effects (20 mg/kg, i.p.) did not alter the extracellular concentrations of noradrenaline (NA), dopamine (DA), serotonin (5-HT) and glutamate in the medial prefrontal cortex (mPFC).
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同义词——
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通路Neuroscience
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靶点GluR
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受体GluR
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研究领域——
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适应症——
化学信息
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CAS Number867276-98-0
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分子量233.23
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分子式C11H11N3O3
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO 中的溶解度 : 50 mg/mL (214.39 mM; 超声助溶 (<60°C)
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SMILESO=C(N1CCOCC1)c1ccc2nonc2c1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Linda J Porrino, et al. Facilitation of task performance and removal of the effects of sleep deprivation by an ampakine (CX717) in nonhuman primates. PLoS Biol. 2005 Sep;3(9):e299.?
