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FPTQ
CAS No. 1025802-62-3
FPTQ ( —— )
产品货号. M22082 CAS No. 1025802-62-3
FPTQ 是 mGluR1 的拮抗剂。FPTQ 是一种合成的异喹啉衍生物。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥3216 | 有现货 |
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| 10MG | ￥5371 | 有现货 |
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| 25MG | ￥7935 | 有现货 |
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| 50MG | 获取报价 | 有现货 |
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| 100MG | 获取报价 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称FPTQ
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述FPTQ 是 mGluR1 的拮抗剂。FPTQ 是一种合成的异喹啉衍生物。
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产品描述FPTQ is an antagonist of mGluR1.FPTQ is a synthetic isoquinoline derivative.Neutrophils translocation in the zebrafish tail-transected model was inhibited by FPTQ.?Neutrophil aggregation was also inhibited by FPTQ in the LPS-stimulated zebrafish model.?Decreased mRNA expression of the pro-inflammatory cytokine genes, interleukin-1β (il-1β) and interleukin-6 (il-6), was found in zebrafish larvae injected with FPTQ.?Additionally, production of nitric oxide was inhibited by FPTQ in RAW264.7 macrophage cells treated with LPS.?Moreover, the mRNA expression of Il-1β and Il-6 suppressed by FPTQ treatment in RAW264.7 macrophage cells, and an enzyme immunoassay showed that FPTQ suppressed the secretion of IL-1β and IL-6 in RAW264.7 cells.?These results demonstrate that FPTQ reduced inflammatory responses and, therefore, suggest that it may be effective as an anti-inflammatory agent.
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体外实验——
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体内实验——
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同义词——
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通路Neuroscience
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靶点GluR
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受体mGluR1
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研究领域——
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适应症——
化学信息
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CAS Number1025802-62-3
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分子量305.32
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分子式C17H12FN5
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纯度>98% (HPLC)
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溶解度——
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SMILESCc1c(nnn1-c1cccnc1F)-c1ccc2cccnc2c1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Geum Ran Kim, Jung Yoon Yang, Kyu-Seok Hwang,et al. Anti-inflammatory effect of a novel synthetic compound 1-((4-fluorophenyl)thio)isoquinoline in RAW264.7 macrophages and a zebrafish model.[J]. Fish & shellfish immunology, 2019.
