Mitoguazone

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Mitoguazone(Methylglyoxal-bis(guanylhydrazone)) 是一种具有有效抗肿瘤活性的合成多羰基衍生物。Mitoguazone 是一种可透过血脑屏障的竞争性的 S-腺苷-蛋氨酸脱羧酶 (S-adenosyl-methionine decarboxylase) 抑制剂，可破坏多胺的生物合成。Mitoguazone 诱导细胞凋亡 (apoptosis)，可抑制 HIV DNA 整合到单核细胞和巨噬细胞中的细胞 DNA 中。Mitoguazone 具可用于急性白血病，霍奇金淋巴瘤和非霍奇金淋巴瘤的研究。

Mitoguazone (Methylglyoxal-bis(guanylhydrazone)) is a synthetic polycarbonyl derivative with potent antineoplastic activity. Mitoguazone is a brain-penetrant and competitive S-adenosyl-methionine decarboxylase (SAMDC) inhibitor that disrupts polyamine biosynthesis. Mitoguazone induces cell apoptosis. Mitoguazone inhibits HIV DNA integration into the cellular DNA in both monocytes and macrophages. Mitoguazone has the potential for acute leukemia, Hodgkin's and non-Hodgkin's lymphoma treatment.

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Apoptosis

Apoptosis

Apoptosis | HIV Protease

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459-86-9

184.2

C5H12N8

>98% (HPLC)

In Vitro:?H2O 中的溶解度 : 50 mg/mL (271.44 mM; ultrasonic and adjust pH to 9 with HCl) DMSO 中的溶解度 : 8.33 mg/mL (45.22 mM; 超声助溶 (<60°C)

C\C(\C=N\NC(N)=N)=N/NC(N)=N

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(-20℃)

With Ice Pack

≥ 2 years