Voclosporin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Voclosporin (ISAtx-247) 是一种钙调神经磷酸酶 (CN; PP2B) 抑制剂。

Voclosporin (ISAtx-247) is a calcineurin (PP2B) (CN) inhibitor.

This novel semi-synthetic calcineurin (CN) inhibitor is designated Voclosporin (ISATX247). The efficacy of Voclosporin as an immunosuppressive agent is examined using an in vitro calcineurin assay. Voclosporin (ISATX247) is a calcineurin inhibitor that has shown more potency than Cyclosporine in vitro.

All animals tolerate Voclosporin (ISATX247) and Cyclosporine A (CsA) very well. There are no severe adverse effects associated with either drug. In the Voclosporin group, all animals except 1 have diarrhea of different durations during the study (mean 2.3 days, range 2 to 7 days). This differs from the CsA and the control groups, where no animals have diarrhea. Mean weight loss at the end of the study is slightly higher in the Voclosporin group than in the CsA and control groups (3.4% vs 2.0% and 1.0%, respectively).

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Metabolic Enzyme/Protease

Phosphatase

Phosphatase

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515814-01-4

1214.62

C63H111N11O12

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : ≥ 50 mg/mL (41.17 mM )

[H][C@@]1(CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@]([H])(NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C(=O)[C@H](CC)NC(=O)[C@]([H])([C@H](O)[C@H](C)C\C=C\C=C)N(C)C(=O)[C@]([H])(C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C1=O)C(C)C

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(-20℃)

With Ice Pack

≥ 2 years