MP07-66

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

MP07-66 是一种新型 FTY720 类似物，没有免疫抑制作用，会导致 PP2A 重新激活，进而引发 CLL 细胞凋亡。

MP07-66 is a novel FTY720-analog devoid of immunosuppressive effects leads to the reactivation of PP2A, which in turn triggers apoptosis of CLL cells.(In Vitro):CLL cells were incubated with increasing concentrations of MP07-66 (0-16 μM) for 24 and 48 hours and then subject to annexin V–PI flow cytometry. The level of apoptosis reached 50% and 80%, at 24 hours and 48 hours, respectively, at a MP07-66 concentration as high as 16 μM, which paralleled PARP cleavage, a marker of caspase-dependent apoptosis. In addition, the phosphorylation status of PP2A targets, namely Akt, GSK-3, and SHP-1, was negatively affected by the treatment with MP07-66, triggering known downstream events promoting apoptosis, such as Mcl-1 degradation and caspase-3 activation.

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Metabolic Enzyme/Protease

Phosphatase

PDE7

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1938056-90-6

323.47

C19H33NO3

>98% (HPLC)

In Vitro:?DMSO : 250 mg/mL (772.87 mM)

CCCCCCOc1ccc(CNCC(OCC)OCC)cc1

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(-20℃)

With Ice Pack

≥ 2 years