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LMPTP INHIBITOR 1 dihydrochloride
CAS No. 2310135-46-5
LMPTP INHIBITOR 1 dihydrochloride ( —— )
产品货号. M28358 CAS No. 2310135-46-5
LMPTP INHIBITOR 1 diHClide 是低分子量蛋白酪氨酸磷酸酶 (LMPTP) 的选择性抑制剂，IC50 为 0.8 μM LMPTP-A。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥1492 | 有现货 |
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| 10MG | ￥2394 | 有现货 |
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| 25MG | ￥3953 | 有现货 |
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| 50MG | ￥5515 | 有现货 |
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| 100MG | ￥7533 | 有现货 |
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| 200MG | ￥10080 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥1881 | 有现货 |
|
生物学信息
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产品名称LMPTP INHIBITOR 1 dihydrochloride
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述LMPTP INHIBITOR 1 diHClide 是低分子量蛋白酪氨酸磷酸酶 (LMPTP) 的选择性抑制剂，IC50 为 0.8 μM LMPTP-A。
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产品描述LMPTP INHIBITOR 1 dihydrochloride is a selective inhibitor of low molecular weight protein tyrosine phosphatase (LMPTP), with an?IC50?of 0.8 μM LMPTP-A.(In Vitro):LMPTP INHIBITOR 1 dihydrochloride is a selective inhibitor of low molecular weight protein tyrosine phosphatase, with an IC50?of 0.8 μM LMPTP-A and shows more potent effect on LMPTP-A versus LMPTP-B. LMPTP inhibitor 1 dihydrochloride (10 μM) also enhances HepG2 IR phosphorylation after insulin stimulation in human HepG2 hepatocytes.(In Vivo):LMPTP inhibitor 1 dihydrochloride is orally bioavailable, and results in appr 680 nM mean serum concentration after treatment of 0.03% w/w, while treatment with 0.05% w/w results in >3 μM; also reverses diabetes in obese mice. LMPTP inhibitor 1 dihydrochloride (0.05% w/w) inhibits LMPTP activity, significantly improves glucose tolerance and decreases fasting insulin levels of diabetic DIO mice, without affecting body weight.
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体外实验LMPTP INHIBITOR 1 (dihydrochloride) is a selective inhibitor of low molecular weight protein tyrosine phosphatase, with an IC50 of 0.8 μM LMPTP-A and shows more potent effect on LMPTP-A versus LMPTP-B. LMPTP inhibitor 1 (Compound 23; 10 μM) also enhances HepG2 IR phosphorylation after insulin stimulation in human HepG2 hepatocytes.
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体内实验LMPTP inhibitor 1 is orally bioavailable, and results in appr 680 nM mean serum concentration after treatment of 0.03% w/w, while treatment with 0.05% w/w results in >3 μM; also reverses diabetes in obese mice. LMPTP inhibitor 1 (0.05% w/w) inhibits LMPTP activity, significantly improves glucose tolerance and decreases fasting insulin levels of diabetic DIO mice, without affecting body weight.
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同义词——
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通路Metabolic Enzyme/Protease
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靶点Phosphatase
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受体E3 Ligase Ligand-Linker Conjugate
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研究领域——
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适应症——
化学信息
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CAS Number2310135-46-5
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分子量517.54
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分子式C28H38Cl2N4O
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : ≥ 64 mg/mL (123.66 mM)
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SMILESCl.Cl.CCN(CC)C(=O)c1ccc(cc1)-c1cc(NCCCN2CCCCC2)c2ccccc2n1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Qiu X, et al. Jiang B. Chemoselective Synthesis of Lenalidomide-Based PROTAC Library Using Alkylation Reaction. Org Lett. 2019;21(10):3838-3841.
产品手册
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