CWHM-1552

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

CWHM-1552 是一种口服有效的恶性疟原虫抑制剂，对 3D7 和 Dd2 strain 的 IC50s 分别是 51 nM and 53 nM。

CWHM-1552 is an orally efficacious inhibitor of P. falciparum with IC50s of 51 nM and 53 nM for 3D7 and Dd2 strain, respectively.

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CWHM-1552 (Compound (-)-32a) (orally; 3-30 mg/kg/day for 4 days) inhibits parasitemia at 99.9% at 30 mg/kg/day and 94% at 10 mg/kg/day. CWHM-1552 (i.v. administration; 2 mg/kg/day for 48 hours) has respectable half-lives (2.7 h) and low clearance in mice. CWHM-1552 has good pharmacokinetic properties and oral efficacy in a mouse model of malaria. CWHM-1552 has an in vivo ED90 of <10 mg/kg/day and ED99 of 30 mg/kg/day, respectively. Animal Model:P. chabaudi ASS infected Mice Dosage:3, 10, 30 mg/kg Administration:Orally; daily for 4 days Result:Inhibited parasitemia at 99.9% at 30 mg/kg/day and 94% at 10 mg/kg/day.Animal Model: Male KM miceDosage:2 mg/kg Administration:I.v. administration; dailyResult:Had respectable half-lives (2.7 h) and low clearance in mice.

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Microbiology/Virology

Parasite

Parasite

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2368253-58-9

387.47

C22H27F2N3O

>98% (HPLC)

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N(C(CC1=CC=C(N(C)C)C=C1)=O)[C@H]2[C@@H](CNC2)C3=CC=C(C(C)(F)F)C=C3

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(-20℃)

With Ice Pack

≥ 2 years