AP-C5

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

AP-C5 选择性抑制鸟苷3'，5' 环一磷酸 (cGMP) 依赖性蛋白激酶 II (cGKII)，pIC50 为 7.2，可用于腹泻疾病的研究。AP-C5 是一种点击化学试剂。它含有 Alkyne 基团，可以和含有 Azide 基团的分子发生铜催化的叠氮-炔环加成反应 (CuAAc)。

AP-C5 displays selective inhibition of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC50 of 7.2, which can be used for the research of diarrheal disease. AP-C5 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

AP-C5 shows potent inhibition of cGMP-dependent cGKII-mediated protein phosphorylation and effective inhibition of cGMP-dependent, CFTR-mediated anion secretion in intestinal tissue.AP-C5 potentiates cAMP signaling by PDE inhibition.AP-C5 (20 μM) partially blocks the heat-stable toxin (STa)-mediated short-circuit current (Isc) response in mouse ileum.

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Microbiology/Virology

Parasite

Parasite

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2234272-10-5

275.31

C16H13N5

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 25 mg/mL (90.81 mM; 超声助溶 (<60°C)

N(CC#C)C=1N=C(C2=CC=C(C=C2)N3C=CN=C3)C=CN1

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(-20℃)

With Ice Pack

≥ 2 years