Calcipotriol monohydrate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

卡泊三醇一水合物是维生素 D3 的类似物，与维生素 D 受体具有高亲和力。卡泊三醇一水合物可用于牛皮癣的研究。

Calcipotriol monohydrate is an analog of Vitamin D3 with a high affinity for the vitamin D receptor. Calcipotriol monohydrate can be used for studies about psoriasis.(In Vitro):Calcipotriol monohydrate (100, 10, and 1 ng/mL) significantly upregulated the expression of NKp30 on the surface of NK cells after 4 h incubation. When NHEK cells are not stimulated with IL-17A or IL-22, Calcipotriol monohydrate slightly enhances (0.2 nM) IL-8 mRNA expression or has no effect (2-20 nM). The addition of IL-17A and IL-22 markedly increased the mRNA expression of IL-8, confirming our previous study. This enhanced IL-8 mRNA expression is suppressed by Calcipotriol monohydrate (2, 20 and 40 nM) in a dose dependent manner.(In Vivo):The weight gain is significantly smaller in the groups treated with Diclofenac plus Calcipotriol monohydrate (p=0.018) and Diclofenac plus DFMO plus Calcipotriol monohydrate (p=0.002) compare with placebo (linear regression model).

——

——

——

Others

Other Targets

——

——

——

147657-22-5

430.629

C27H42O4

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (232.22 mM)

O.[H][C@@]12CC[C@H]([C@H](C)\C=C\[C@@H](O)C3CC3)[C@@]1(C)CCC\C2=C/C=C1/CC(O)CC(O)C1=C

——

(-20℃)

With Ice Pack

≥ 2 years