1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

黄腐酚（Xanthohumol），异戊二烯查酮类黄酮，是从啤酒花中纯化得到的具有多种生物功能的天然产物。黄腐酚对 HIV-1 有效，可能作为一种有趣的先导化合物。它可能代表一种治疗 HIV-1 感染的新型化疗化合物。

Xanthohumol, prenylchacone flavonoid, is a natural product with multi-biofunctions purified from Hops Humulus lupulus. Xanthohumol is effective against HIV-1 and might serve as an interesting lead compound. It may represent a novel chemotherapeutic agent for HIV-1 infection.(In Vitro):Xanthohumol inhibited HIV-1 induced cytopathic effects, the production of viral p24 antigen and reverse transcriptase in C8166 lymphocytes at non-cytotoxic concentration. The EC50 values were 0.82, 1.28 and 0.50 microg/ml, respectively. The therapeutic index (TI) was about 10.8. Xanthohumol also inhibited HIV-1 replication in PBMC with EC50 value of 20.74 microg/ml. The activity of recombinant HIV-1 reverse transcriptase and the HIV-1 entry were not inhibited by Xanthohumol. (In Vivo):Young and old mice were fed a diet supplemented with Xanthohumol for 8 weeks. Spatial memory was assessed with the Morris water maze and protein palmitoylation quantified. The young Xanthohumol-treated mice showed a significant improvement in cognitive flexibility. This evidence suggests that Xanthohumol may play a role in improving cognitive flexability in young animals, but it appears to be ineffective in adjusting the palmitoylation status of neuronal proteins in aged individuals.

——

——

Xanthohumol

Apoptosis

Apoptosis

Apoptosis

——

——

569-83-5

354.4

C21H22O5

>98% (HPLC)

——

CC(C)=CCc(c(O)c(C(C=Cc(cc1)ccc1O)=O)c(OC)c1)c1O

——

(-20℃)

With Ice Pack

≥ 2 years