Mesaconine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Mesaconine 是 Aconitum carmichaelii Debx 的一种成分。Mesaconine 具有强心作用和抗 NF-κB 活性。新乌头碱可能是麻黄附子细辛汤抗炎、免疫抑制的物质基础之一。

Mesaconine is an ingredient from Aconitum carmichaelii Debx.. Mesaconine has a cardiac effect and anti-NF-κB activity. Mesaconine may be part of the material basis of Mahuang Fuzi Xixin decoction on anti-inflammation and immune suppression.(In Vitro):The anti-inflammatory effect of SFI was verified in vitro with endothelial cells. After detecting the cell viability, the expression of interleukin-6 (IL-6), inhibitor of nuclear factor kappa-B kinase (IKK), phosphorylated IKK, phosphorylated NF-κB and phosphorylated IκB-α± from the supernatant were determined. SFI could significantly suppress inflammatory responses, and the mechanism may be via an NF-κB-dependent pathway. Mesaconine is the first reported SFI compounds to have NF-κB inhibitor activity.

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Apoptosis

IL Receptor

IL Receptor

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6792-09-2

485.574

C24H39NO9

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (205.94 mM)

COC[C@]12CN(C)[C@@H]3[C@@H]4[C@H](OC)[C@H]1[C@]3([C@@H]1C[C@@]3(O)[C@H](O)[C@@H]1[C@]4(O)[C@@H](O)[C@@H]3OC)[C@H](C[C@H]2O)OC

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(-20℃)

With Ice Pack

≥ 2 years