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Tocilizumab
CAS No. 375823-41-9
Tocilizumab ( —— )
产品货号. M22142 CAS No. 375823-41-9
Tocilizumab (抗 IL-6R) 是一种人源化单克隆抗体，可与白细胞介素 6 受体结合。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥2214 | 有现货 |
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| 5MG | ￥3781 | 有现货 |
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| 10MG | ￥5396 | 有现货 |
|
| 25MG | ￥8110 | 有现货 |
|
| 50MG | ￥10881 | 有现货 |
|
| 100MG | ￥14220 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Tocilizumab
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Tocilizumab (抗 IL-6R) 是一种人源化单克隆抗体，可与白细胞介素 6 受体结合。
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产品描述Tocilizumab anti-IL-6R) is a humanized monoclonal antibody that binds to the interleukin-6 receptor.
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体外实验Cell Proliferation Assay Cell Line:Human-derived HARA-B cells Concentration:1 ng/mL, 10 ng/mL, and 100 ng/mL Incubation Time:24 hours, 48 hours Result:Inhibited the IL-6R expressed on human-derived HARA-B cells.Cell Cytotoxicity Assay Cell Line:Ba/F3-gp130-IL-6R cells Concentration:0.001–10000 μg/ml Incubation Time:2 days Result:Inhibited Ba/F3-gp130-IL-6R cell proliferation. Western Blot Analysis Cell Line:SAS cells Concentration:1 μM Incubation Time:6 hours Result:Reduced the phosphorylation of STAT3.RT-PCR Cell Line:SAS cells Concentration:1-5 μM Incubation Time:24 hoursResult:Reduced VEGF mRNA expression.
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体内实验Animal Model:A brain metastasis model of lung tumor cells by inoculating HARA-B cells in nude mice Dosage:1.0 mg/100 μL Administration:Intravenous injection; 1.0 mg/100 μL; twice a week, three weeks Result:Led the volume of each metastatic focus significantly smaller.Animal Model:SCID mice with SAS cells Dosage:100 μg/mL Administration:Intraperitoneal injection;100 μg/mL; every 48 hours; 20days Result:Suppressed the growth of advanced tumors.
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同义词——
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通路Apoptosis
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靶点IL Receptor
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受体IL Receptor
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研究领域——
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适应症——
化学信息
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CAS Number375823-41-9
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分子量148 kDa
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分子式——
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纯度>98% (HPLC)
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溶解度——
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SMILES——
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Garbers C, et al. Inhibition of classic signaling is a novel function of soluble glycoprotein 130 (sgp130), which is controlled by the ratio of interleukin 6 and soluble interleukin 6 receptor. J Biol Chem. 2011 Dec 16;286(50):42959-70
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