Chrysosplenol D

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Chrysosplenol D 是一种外排泵抑制剂，可以增强商业上重要的抗生素和抗疟药的活性。

Chrysosplenol D, an efflux pump inhibitor that can potentiate the activity of commercially important antibiotics and antimalarials.(In Vitro):Trace amounts of the antimalarial sesquiterpene lactone artemisinin may account for the activity of the n-hexane fraction but only the methoxylated flavonoids artemetin, chrysoplenetin, Chrysosplenol D and cirsilineol can account for the activity of the chloroform extract. These purified flavonoids were found to have IC50 values at 2.4 - 6.5 x 10(-5)M against P. falciparum in vitro compared with an IC50 value of about 3 x 10(-8)M for purified artimisinin. Chrysosplenol D inhibited the viability of the MDA-MB-231 TNBC cells after 48 h with IC50 values of 11.6 μM. The most sensitive cell line towards Chrysosplenol D was the non-small-cell lung carcinoma (NSCLC) cell line A549 and the most resistant one was the androgen-independent prostate carcinoma cell line PC-3. The hormone-sensitive breast cancer cells MCF7 exhibited high resistance towards Chrysosplenol D treatment.(In Vivo):In mice, administration of Chrysosplenol D (1 and 1.5μmol/cm^2) inhibited croton oil-induced ear edema (37.76-65.89%, all P<0.05) in a manner similar to indomethacin (0.5, 1 and 1.5μmol/cm^2; 55.63-84.58%). Chrysosplenol D (0.07, 0.14 and 0.28mmol/kg) protected against LPS-induced systemic inflammatory response syndrome (SIRS) in mice (all P<0.05), in a manner similar to dexamethasone (0.03mmol/kg). Chrysosplenol D suppressed LPS-induced release of IL-1 beta, IL-6 and MCP-1, inhibited cell migration, and reduced LPS-induced IκB and c-JUN phosphorylation in Raw264.7 cells.

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Apoptosis

IL Receptor

IL Receptor

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14965-20-9

360.318

C18H16O8

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (138.77 mM)

COc1cc2oc(-c3ccc(O)c(O)c3)c(OC)c(=O)c2c(O)c1OC

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(-20℃)

With Ice Pack

≥ 2 years