021-51111890
购物车（）
sales@molnova.cn
Cyclosporin D
CAS No. 63775-96-2
Cyclosporin D ( —— )
产品货号. M30364 CAS No. 63775-96-2
Cyclosporin D is a metabolite of cyclosporin A, an immunosuppressant drug that binds cyclophilin D, inhibiting the phosphatase activity of calcineurin in T cells.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥3971 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称Cyclosporin D
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述Cyclosporin D is a metabolite of cyclosporin A, an immunosuppressant drug that binds cyclophilin D, inhibiting the phosphatase activity of calcineurin in T cells.
-
产品描述Cyclosporin D is a metabolite of cyclosporin A, an immunosuppressant drug that binds cyclophilin D, inhibiting the phosphatase activity of calcineurin in T cells.(In Vitro):Cyclosporine D inhibits Ca2+/calmodulin dependent EF-2 phosphorylation in vitro.(In Vivo):Cyclosporine D is a potent inhibitor in vivo of phorbol ester TPA-induced biological effects in mouse skin.
-
体外实验Cyclosporine D inhibits Ca2+/calmodulin dependent EF-2 phosphorylation in vitro.
-
体内实验Cyclosporine D is a potent inhibitor in vivo of phorbol ester TPA-induced biological effects in mouse skin.
-
同义词——
-
通路Apoptosis
-
靶点IL Receptor
-
受体——
-
研究领域——
-
适应症——
化学信息
-
CAS Number63775-96-2
-
分子量1216.64
-
分子式C63H113N11O12
-
纯度>98% (HPLC)
-
溶解度In Vitro:?DMSO : 25 mg/mL (20.55 mM)
-
SMILES——
-
化学全称Sequence:cyclo ({Aaa}-Val-{Sar}-Leu-Val-Leu-Ala-Ala-Leu-Leu-{d-Val})
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
Gschwendt M, et al. The weak immunosuppressant cyclosporine D as well as the immunologically inactive cyclosporine H are potent inhibitors in vivo of phorbol ester TPA-induced biological effects in mouse skin and of Ca2+/calmodulin dependent EF-2 phosphorylation in vitro. Biochem Biophys Res Commun. 1988 Jan 29;150(2):545-51.
产品手册
关联产品
-
Xeligekimab
Xeligekimab (GR 1501) 是一种抗人白细胞介素 17A (IL-17A) 人源化单克隆抗体。Xeligekimab 抑制促炎级联反应。
-
Pranlukast
Pranlukast 是一种半胱氨酰白三烯受体 1 拮抗剂。
-
Nothofagin
Nothofagin 是一种二氢查尔酮，是从如意宝 (Aspalathus linearis) 中分离得到的。Nothofagin 通过阻断钙 (calcium) 内流来下调 NF-κB 的转运。Nothofagin 具有抗氧化活性，可改善各种炎症反应，例如脓毒症反应和血管炎症。
