PHYTOSPHINGOSINE

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

植物鞘氨醇是一种具有抗癌特性的磷脂。在癌细胞中，植物鞘氨醇通过激活 caspase 8 和 Bax 易位诱导细胞凋亡。

Phytosphingosine is a phospholipid with anticancer properties. In cancer cells, Phytosphingosine induces cell apoptosis through activation of caspase 8 and translocation of Bax.

Cell Viability Assay Cell Line:A549, LLC, BEAS-2B Concentration:1 μg/mL, 2 μg/mL, 3 μg/mL, 4 μg/mL, 5 μg/mL Incubation Time:24 h, 48 h Result:Significantly inhibited cell proliferation in a concentration- and time-dependent manner.Cell Cycle Analysis Cell Line:A549 Concentration:1 μg/mL, 3 μg/mL, 5 μg/mL Incubation Time:24 h Result:Significantly increased the proportion of G2/M phase cells.Western Blot Analysis Cell Line:A549 Concentration:1 μg/mL, 3 μg/mL, 5 μg/mL Incubation Time:24 hResult:Up-regulated the pro-apoptotic factor Bax protein level and down-regulated the anti-apoptotic factor Bcl-2 protein level.Promoted the release of cytochrome c to up-regulate caspase 9 and caspase 3 levels, leading to PARP cleavage.

——

——

Apoptosis

Apoptosis

PDGFR|FGFR|Src|p38|TNF-α

——

——

554-62-1

317.514

C18H39NO3

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (157.48 mM)

CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@@H](N)CO

——

(-20℃)

With Ice Pack

≥ 2 years