L-Cysteinesulfinic acid monohydrate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

L-Cysteinesulfinic Acid monosculpture 是大鼠代谢型谷氨酸受体 (mGluRs) 的有效激动剂。

L-Cysteinesulfinic acid monohydrate is a potent agonist at rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively.(In Vitro):L-Cysteinesulfinic acid (monohydrate) is an endogenous agonist of a metabotropic receptor coupled to stimulation of phospholipase D (PLD) activity. L-CSA (monohydrate) is an endogenous agonist of the PLD-coupled metabotropic excitatory amino acids (EAA) receptor. L-CSA (monohydrate) selectively activates the PLD-coupled receptor. 1 mM L-CSA (monohydrate) induces a significant increase in PLD activity in hippocampal slices, whereas 1 mM concentrations of L-glutamate, L-aspartate, and L-HCA are without effect. L-CSA (monohydrate) elicits a dose-dependent increase in PLD activity in rat hippocampal slices in the presence of iGluR antagonists, with an approximate EC50 of 500 uM. The PLD response induced by 1 mM L-CSA (monohydrate) is not significantly decreased in the presence of 1 uM tetrodotoxin, suggesting that this response is not dependent upon L-CSA (monohydrate)-induced increases in cell firing.

L-Cysteinesulfinic acid is an endogenous agonist of a metabotropic receptor coupled to stimulation of phospholipase D (PLD) activity. L-CSA is an endogenous agonist of the PLD-coupled metabotropic excitatory amino acids (EAA) receptor. L-CSA selectively activates the PLD-coupled receptor. 1 mM L-CSA induces a significant increase in PLD activity in hippocampal slices, whereas 1 mM concentrations of L-glutamate, L-aspartate, and L-HCA are without effect. L-CSA elicits a dose-dependent increase in PLD activity in rat hippocampal slices in the presence of iGluR antagonists, with an approximate EC50 of 500 uM. The PLD response induced by 1 mM L-CSA is not significantly decreased in the presence of 1 uM tetrodotoxin, suggesting that this response is not dependent upon L-CSA-induced increases in cell firing.

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Neuroscience

GluR

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207121-48-0

171.17

C3H9NO5S

>98% (HPLC)

In Vitro:?H2O : 41.67 mg/mL (243.44 mM)

O.N[C@@H](CS(O)=O)C(O)=O

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(-20℃)

With Ice Pack

≥ 2 years