Memantine hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

美金刚是一种非竞争性 NMDA 受体拮抗剂。当使用表达重组大鼠 NMDA 受体的 HEK293 细胞时，美金刚以剂量和电压依赖性方式抑制 L-谷氨酸介导的反应。

Memantine is an uncompetitive NMDA receptor antagonist. When using HEK293 cells express recombinant rat NMDA receptors, memantine shows inhibition of L-glutamate-mediated response with a dose- and voltage-dependent manner. Memantine also has a rapid unblocking kinetics. Memantine is used clinically in spasticity, Parkinson's disease and Alzheimer's disease. Memantine is found to attenuate the deleterious action of Aβ in the in vitro numerous studies. It is probably due to the decreased tau phosphorylation caused by memantine.(In Vitro):Memantine (hydrochloride) (D-145 (hydrochloride)) is a moderate-affinity, uncompetitive, voltage-dependent, NMDA-receptor antagonist with fast on/off kinetics that inhibits excessive calcium influx induced by chronic overstimulation of the NMDA receptor. Memantine is approved in the US and the EU for the treatment of patients with moderate to severe dementia of the Alzheimer's type. Memantine has considerable therapeutic potential for the myriad of clinical entities associated with NMDA receptor-mediated neurotoxicity. Memantine blocked 200 microM NMDA-evoked responses with a 50% inhibition constant (IC50) of approximately 1 microM at -60 mV and an empirical Hill coefficient of approximately.

Memantine (hydrochloride) (D-145 (hydrochloride)) is a moderate-affinity, uncompetitive, voltage-dependent, NMDA-receptor antagonist with fast on/off kinetics that inhibits excessive calcium influx induced by chronic overstimulation of the NMDA receptor. Memantine is approved in the US and the EU for the treatment of patients with moderate to severe dementia of the Alzheimer's type. Memantine has considerable therapeutic potential for the myriad of clinical entities associated with NMDA receptor-mediated neurotoxicity. Memantine blocked 200 microM NMDA-evoked responses with a 50% inhibition constant (IC50) of approximately microM at -60 mV and an empirical Hill coefficient of approximately .

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Akatinol | Axura | Ebix | Namenda | NSC 102290 | SUN Y7017

Neuroscience

GluR

AMPA| NMDA receptor| Kainate receptor

Neurological Disease

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41100-52-1

215.76

C12H22ClN

>98% (HPLC)

Ethanol: 43 mg/mL (199.29 mM); Water: 30 mg/mL (139.04 mM); DMSO: 43 mg/mL (199.29 mM)

Cl.CC12CC3CC(C)(C1)CC(N)(C3)C2

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(-20℃)

With Ice Pack

≥ 2 years