BiP inducer X

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

BiP 诱导剂 X 是免疫球蛋白重链结合蛋白 (BiP)/GRP78 的选择性诱导剂和 ER 伴侣诱导剂。 BiP 诱导剂 X 可防止神经元和视网膜细胞系的细胞死亡。

BiP inducer X is a selective inducer of immunoglobulin heavy chain binding protein (BiP)/GRP78 and an ER chaperone inducer. BiP inducer X prevents cell death in neurons and retinal cell lines.(In Vitro):Pretreatment of BiP inducer X (5?μM; 12 hours) inhibits cell death induced by ER stress involving inhibited activation of caspases 3/7 and 4. In SK-N-SH cells, BiP inducer X (5?μM; 0-12 hours) increases BiP protein and is mediated by activation of ER stress response elements (ERSEs) through the ATF6 pathway.(In Vivo):In male adult ddY mice, BiP inducer X (20?μg) reduces ER stress-induced apoptosis induced in the penumbra by MCA occlusion. BiP inducer X reduces the insults due to cerebral infarction.

BiP inducer X (5?μM; 0-12 hours; SK-N-SH cells) increase BiP protein.The induction of BiP by BiP inducer X (BIX) is mediated by activation of ER stress response elements (ERSEs) through the ATF6 pathway.BiP inducer X (5?μM; 12 hours; pretreatment with SK-N-SH cells) inhibits cell death induced by ER stress involving inhibited activation of caspases 3/7 and 4.

BiP inducer X administration reduces the insults due to cerebral infarction.A 20?μg portion of BiP inducer X administration reduces ER stress-induced apoptosis induced in the penumbra by MCA occlusion. Animal Model:Male adult ddY mice weighing 24-34?g (Japan SLC)Dosage:20?μg (2?μl)Administration:Intracerebroventricularly Result:Significantly increased the level of BiP protein 24?h after administration, confirming that administration of BIX induces BiP protein in vivo.

BIX

Apoptosis

Apoptosis

NFAT5

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101714-41-4

209.22

C9H7NO3S

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (238.98 mM)

Oc1ccc(cc1O)C(=O)CSC#N

——

(-20℃)

With Ice Pack

≥ 2 years