ZZW-115 hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

ZZW-115 盐酸盐抑制 NUPR1 的活性。

ZZW-115 hydrochloride inhibits the activity of NUPR1.

Cell Viability Assay Cell Line:ANOR cells, MiaPaCa-2, 02-063, 01008, LIPC, 02136, HN01,01046, AOIPC, Foie8b, HN14 cells Concentration:0.1- 33 μM Incubation Time:72 hours Result:Was efficient in killing cancer cells, with an IC50 in the range of 0.84 μM (ANOR) to 4.93 μM (HN14).Cell Proliferation Assay Cell Line:U87, A375, U2OS, SaOS-2, HT29, SK-CO-1, LS174T, H1299 and H358, HepG2, PC3, THP-1, Daudi, Jurkat and MDA-MB-231 cells Concentration:0-100 μM Incubation Time:24 or 72 hours Result:Was efficient to kill these tumor cells with an IC50 in the range of 0.42 μM (Hep2G cells) to 7.75 μM (SaOS-2 cells).

Animal Model:NMRI-Foxn1nu/Foxn1nu mice (nude mice) xenografted with MiaPaCa-2 cells Dosage:5, 2.5, 1.0, or 0.5 mg/kg Administration:Injection; daily for 30 days Result:When the mice were injected with 5 mg/kg ZZW-115 hydrochloride, the tumors stopped growing a few days after treatment and their size decreased progressively, almost disappearing at the end of the treatment.

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Apoptosis

Apoptosis

5-HT1F

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10122-45-9

573.97

C24H34Cl3F3N4S

>98% (HPLC)

In Vitro:?DMSO : 83.33 mg/mL (145.18 mM)

FC(F)(F)C1=CC=C(SC2=C3C=CC=C2)C(N3CCCN4CCN(CC4)CCN(C)C)=C1.[H]Cl.[H]Cl.[H]Cl

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(-20℃)

With Ice Pack

≥ 2 years