Pyrazoloacridine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Pyrazoloacridine 是一种核酸结合剂，在 K562 细胞中抑制拓扑 I 和 II 的活性，IC50 为 1.25 μM。吡唑吖啶显示出抗癌活性。

Pyrazoloacridine is a nucleic acid binding agent that inhibits the activity of topo I and II with an IC50 of 1.25 μM in K562 cells. Pyrazoloacridine shows anti-cancer activity.(In Vitro):In oxic and hypoxic HCT-8 cells, Pyrazoloacridine exhibits IC50 values of 10.7 μM and 4.5 μM. Pyrazoloacridine causes delayed DNA fragmentation in MCF-7 cells and induces apoptosis in P53-deficient Hep 3B cells. Pyrazoloacridine exhibits activities against cisplatin- and paclitaxel-resistant ovarian cancer.

Pyrazoloacridine (NSC 366140, PD 115934) exhibits IC50 values of 10.7 μM and 4.5 μM for oxic and hypoxic HCT-8 cells.Pyrazoloacridine (NSC 366140, 2-4 μM) abolishes the catalytic activity of both topo I and topo II in vitro.Pyrazoloacridine (NSC 366140) displays activity against cisplatin- and paclitaxel-resistant ovarian cancer.Pyrazoloacridine (NSC 366140) has been shown to cause delayed DNA fragmentation in MCF-7 breast cancer cells.Pyrazoloacridine (NSC 366140) induces apoptosis in P53-deficient Hep 3B human hepatoma cells.Cell Cytotoxicity Assay Cell Line:K562 Myeloid Leukemia Cells.Concentration:0-500 μM.Incubation Time:1 h or 24 h.Result:When K562 cells were incubated with PA for 1 h and then plated in soft agar, an IC50 of -50 μM was observed. In contrast, when cells were incubated for 24 h with PA, the IC50 was 1.25 μM.

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PD 115934 | PD-115934 | PD 115,934 | NSC 366140 | NSC-366140

Apoptosis

Apoptosis

Akt|PP2A|Apoptosis|CIP2A

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99009-20-8

367.409

C19H21N5O3

>98% (HPLC)

In Vitro:?DMSO : 16.67 mg/mL (45.37 mM)

COc1ccc2[nH]c3c(ccc4n(CCCN(C)C)nc(c34)c2c1)[N+]([O-])=O

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(-20℃)

With Ice Pack

≥ 2 years