Phenformin ( —— )

产品货号. M33658 CAS No. 114-86-3

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HNMR

HPLC

MSDS

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产品名称

Phenformin
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Phenformin (1-phenethylbiguanide) 是一种具有口服活性的抗糖尿病和抗癌化合物。Phenformin 有相关乳酸性酸中毒的发生率。Phenformin 通过激活 AMPK 并阻断 mTOR 通路发挥作用。Phenformin 也是 P-糖蛋白 (P-gp) 的底物和 OXPHOS 抑制剂。Phenformin 诱导癌细胞凋亡 (apoptosis)。
产品描述

Phenformin (1-phenethylbiguanide) is an orally active antidiabetic and anticancer agent. Phenformin has an incidence of associated lactic acidosis. Phenformin acts through acting AMPK activation and blocking mTOR pathway. Phenformin is also a substrate of P-glycoprotein (P-gp), and an OXPHOS inhibitor. Phenformin induces cancer cell apoptosis.
体外实验

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体内实验

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同义词

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通路

Apoptosis
靶点

Apoptosis
受体

Apoptosis
研究领域

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适应症

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1. García Rubi?o ME, et al. Phenformin as an Anticancer Agent: Challenges and Prospects. Int J Mol Sci. 2019 Jul 5;20(13):3316.?

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