Licostinel

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Licostinel 是一种谷氨酸受体拮抗剂。 Licostinel 可预防永久性局灶性脑缺血。

Licostinel is a glutamate receptor antagonist. Licostinel protects against permanent focal cerebral ischemia.

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Animal Model:The permanent model of middle cerebral artery occlusion in fisher 344 rats and CD-1 mice. The transient model of focal ischemia in Wistar and Sprague –Dawley rats.Dosage:5 mg/kg bolus 3.5 mg/kg/h for 6h, 10 mg/kg bolus 7.0 mg/kg/h for 6h Administration:A single intravenous injection bolus continuous infusionResult:Decreased infarct size.Animal Model:Male Sprague-Dawley rats Dosage:20, 40, 80 mg/kg for intraperitoneal injection (i.p.) bolus 7 mg/kg/h , 30mins Administration:Intravenous injection (i.v.) bolus continuous infusionResult:Reduced the rate of spreading depression and EEG activity in the rat brain in a dose-dependent manner.

ACEA-1021 | ACEA 1021 | ACEA1021 | CGP-63446 | CGP 63446

Neuroscience

GluR

Nucleoside

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153504-81-5

276.03

C8H3Cl2N3O4

>98% (HPLC)

In Vitro:?DMSO : 12.5 mg/mL (45.28 mM)

[O-][N+](=O)c1c(Cl)c(Cl)cc2[nH]c(=O)c(=O)[nH]c12

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(-20℃)

With Ice Pack

≥ 2 years