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IWP 4
CAS No. 686772-17-8
IWP 4 ( IWP4 | IWP 4 | IWP-4 )
产品货号. M17568 CAS No. 686772-17-8
IWP-4 是一种有效的 Wnt 抑制剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥1169 | 有现货 |
|
| 10MG | ￥1881 | 有现货 |
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| 25MG | ￥3302 | 有现货 |
|
| 50MG | ￥4771 | 有现货 |
|
| 100MG | ￥6543 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称IWP 4
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述IWP-4 是一种有效的 Wnt 抑制剂。
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产品描述IWP-4 is a novel potent inhibitor of Wnt/β-catenin signaling.
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体外实验IWP-4 is a small molecule Wnt inhibitor with an IC50 of 25 nM. IWP-4 induces the expression of cardiac markers, including cardiac troponin I (CTNI) and cardiac myosin heavy chain bright cells (MYHhi +). IWP-4 also results in the appearance of beating foci (0.44±0.10 SEM beats per second), which is absent in all cultures not receiving IWP-4. Further, flow cytometric analysis shows that there are significantly more MYHlo + cells in IWP-4 treated cultures (P<0.0002) compare with untreated cultures at day 16, being 17.0±1.3 SD% and 5.4±1.4 SD%, respectively. Quantification of NKX2-5 protein expression shows that 63% (481/817) of IWP-4 treated cells display nuclear NKX2-5 expression. Mesenchymal precursor cells (MPCs) treated with IWP-4 show no significant changes in the expression of AXIN2, CTNNB1 and GSK3B as compare to osteogenic medium alone on day 7, but MPCs treated with IWP-4 express elevates levels of DKK1 and GSK3β on day 21.IWP-4 also causes a significant down regulation of SPARC and COL1A1.
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体内实验——
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同义词IWP4 | IWP 4 | IWP-4
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通路Neuroscience
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靶点GluR
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受体Wnt
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研究领域——
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适应症——
化学信息
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CAS Number686772-17-8
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分子量496.6
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分子式C23H20N4O3S3
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纯度>98% (HPLC)
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溶解度DMSO : 5 mg/mL. 10.07 mM;
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SMILESCOc1ccccc1-n1c(SCC(=O)Nc2nc3ccc(C)cc3s2)nc2CCSc2c1=O
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化学全称N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-3-(2-methoxyphenyl)-4-oxothieno[3,2-d]pyrimidin-2-yl)thio]-acetamide
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Lian X, et al. Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling. Proc Natl Acad Sci U S A. 2012 Jul 3;109(27):E1848-57.
