Triparanol

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Triparanol 干扰 Hedgehog 信号分子的翻译后修饰及其受体 PTCH1 的甾醇感应结构域，导致 Hedgehog 信号传导下调。

Triparanol interferes with posttranslational modification of Hedgehog signaling molecules as well as the sterol sensing domain of its receptor PTCH1, leading to down-regulation of Hedgehog signaling. Triparanol suppresses human tumor growth and is an antilipemic agent with high ophthalmic toxicity.(In Vitro):Triparanol is an effective cholesterol biosynthesis inhibitor blocking the 24-dehydrocholesterol reductase. Triparanol can block proliferation and induce apoptosis in multiple human cancer cells including lung, breast, liver, pancreatic, prostate cancer, and melanoma cells, and growth inhibition can be rescued by the exogenous addition of cholesterol.

Triparanol can block proliferation and induce apoptosis in multiple human cancer cells including lung, breast, liver, pancreatic, prostate cancer and melanoma cells, and growth inhibition can be rescued by exogenous addition of cholesterol.

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NSC 65345 | NSC-65345 | NSC65345

Apoptosis

Apoptosis

A2A/A1

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78-41-1

438.01

C27H32ClNO2

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (114.16 mM)

CCN(CC)CCOc1ccc(cc1)C(O)(Cc1ccc(Cl)cc1)c1ccc(C)cc1

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(-20℃)

With Ice Pack

≥ 2 years