Triglycidyl isocyanurate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Triglycidyl isocyanurate 是一种三氮烯三环氧化物，具有抗肿瘤和抗血管生成活性。它通过激活 p53 抑制人非小细胞肺癌细胞的生长。异氰脲酸三缩水甘油酯烷基化并交联 DNA，从而抑制 DNA 复制。它诱导细胞凋亡，可用于癌症研究。

Triglycidyl isocyanurate is a triazene triepoxide with antineoplastic and antiangiogenic activity. It inhibits growth of human non-small cell lung cancer cells by activating p53. Triglycidyl isocyanurate alkylates and cross-links DNA, thereby inhibiting DNA replication. It induces cell apoptosis and can be used for cancer research. Triglycidyl isocyanurate is also used in various polyester powder coatings in the metal finishing industry.(In Vitro):Triglycidyl isocyanurate (0-30 μM; 48?hours) inhibits expression of akt1/2/3 and phosphorylated Aktser473/474/472 of A549, H460 and H1299 tumorspheres, however, the cleavage of PARP and procaspase-3 plus the emergent active caspase-3 fragment are only visible in H460 and A549 tumorspheres. Triglycidyl isocyanurate (0-30 μM; 48?hours) reduces the growth of spheroids of human non-small-cell-lung cancer cells in culture, it leads to a gradual reduction in size for tumorspheres of A549, H460 and H1299 cells.(In Vivo):Triglycidyl isocyanurate (subcutaneous injection; 1.8 and 3.6 mg/kg; every 2–3 days for total seven times; 30 days) suppresses the growth of xenograft tumors without effect on weight in nude mice.

Triglycidyl isocyanurate?(0-30 μM; 48?hours) reduces the growth of spheroids of human non-small-cell-lung cancer cells in culture, it leads to a gradual reduction in size for tumorspheres of A549, H460 and H1299 cells.Triglycidyl isocyanurate (0-30 μM; 48?hours) inhibits expression of akt1/2/3 and phosphorylated Aktser473/474/472?of A549, H460 and H1299 tumorspheres, however, the?cleavage?of PARP and?procaspase-3?plus the emergent active?caspase-3?fragment are only visible in H460 and A549 tumorspheres. Cell Viability Assay Cell Line:A549, H460 and H1299 cells Concentration:0 μM; 5 μM; 10 μM; 30 μM Incubation Time:48 hours Result:Inhibited tumor cells growth in soft agar.Western Blot AnalysisCell Line:A549, H460 and H1299 cells Concentration:0 μM; 5 μM; 10 μM; 30 μM Incubation Time:48 hours Result:Inhibited akt1/2/3 expression and p-aktser473/474/472 expression of A549, H460 and H1299 tumorspheres

Triglycidyl isocyanurate (subcutaneous injection; 1.8 and 3.6 mg/kg; every 2–3 days for total seven times; 30 days) suppresses the growth of xenograft tumors and has no effects on weight in nude mice. Animal Model:Female nu/nu mice with Huh7 cells subcutaneously injected into the dorsal area Dosage:1.8mg/kg and 3.6 mg/kg Administration:Subcutaneous injection; every 2–3 days for total seven times; 30 days Result:Inhibited the growth of xenograft tumors.

Tris(2,3-epoxypropyl) Isocyanurate | TGI | TGIC | Teroxirone

Apoptosis

Apoptosis

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2451-62-9

297.267

C12H15N3O6

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (168.20 mM)

O=c1n(CC2CO2)c(=O)n(CC2CO2)c(=O)n1CC1CO1

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(-20℃)

With Ice Pack

≥ 2 years