Nitroflurbiprofen

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Nitroflurbiprofen 是一种释放 NO 的 COX 抑制剂，可调节门静脉高压性肝硬化大鼠肝内血管张力的增加。

Nitroflurbiprofen is a NO-releasing COX inhibitor and modulates the increased intrahepatic vascular tone in portal hypertensive cirrhotic rats.(In Vivo):Nitroflurbiprofen (45 mg/kg; i.p.) improves portal hypertension without major adverse effects in thioacetamide-induced cirrhotic rats by attenuating intrahepatic vascular resistance, endothelial dysfunction, and hepatic hyperreactivity to vasoconstrictors.

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In vivo hemodynamic measurements (n = 8/condition) and evaluation of the increased intrahepatic resistance by in situ perfusion (n=5/condition) are performed in rats with thioacetamide-induced cirrhosis that receive either Nitroflurbiprofen (45 mg/kg), Flurbiprofen (30 mg/kg, equimolar concentration to Nitroflurbiprofen), or vehicle by intraperitoneal injection 24 hours and 1 hour prior to the measurements. Treatment with Nitroflurbiprofen, an NO-releasing cyclooxygenase inhibitor, improves portal hypertension without major adverse effects in thioacetamide-induced cirrhotic rats by attenuating intrahepatic vascular resistance, endothelial dysfunction, and hepatic hyperreactivity to vasoconstrictors.

HCT 1206 | NO-flurbiprofen | Nitroxybutyl flurbiprofen

Chromatin/Epigenetic

COX

Influenza A and B| Nucleoside Antimetabolite/Analog

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158836-71-6

361.369

C19H20FNO5

>98% (HPLC)

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CC(C(=O)OCCCCO[N+]([O-])=O)c1ccc(c(F)c1)-c1ccccc1

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(-20℃)

With Ice Pack

≥ 2 years