Paprotrain ( (alphaZ)-alpha-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile )

产品货号. M26357 CAS No. 57046-73-8

Paprotrain 抑制 MKLP-2 的 ATPase 活性，IC50 为 1.35 μM，Ki 为 3.36 μM。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
5MG	￥392	有现货
10MG	￥550	有现货
25MG	￥923	有现货
50MG	￥1609	有现货
100MG	￥2385	有现货
200MG	￥3492	有现货
500MG	￥5535	有现货
1G	获取报价	有现货
1 mL x 10 mM in DMSO	￥411	有现货

产品询价大包装询价加入购物车

生物学信息

产品名称

Paprotrain
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Paprotrain 抑制 MKLP-2 的 ATPase 活性，IC50 为 1.35 μM，Ki 为 3.36 μM。
产品描述

Paprotrain inhibits the ATPase activity of MKLP-2 with an IC50 of 1.35 μM and a Ki of 3.36 μM.(In Vitro):Paprotrain-treated porcine oocytes suffer failure of nuclear maturation.?The number of oocytes arrested at early MI stage increase in a dose-dependent manner after KIF20A activity inhibition, while the percentage of oocytes that reach ATI and MII stages decrease after treatment.
体外实验

Paprotrain has been screened on a panel of CNS kinases. While inactive (IC50 >10 μM) on CDK5 and GSK3, it has shown a moderate activity on DYRK1A (IC50=5.5 μM). Time-lapse microscopy shows that disrupting MKlp2 expression with paprotrain results in polar body extrusion failure. This could be rescued after rescuing oocytes from paprotrain in fresh medium. Cell cycle analysis shows that most oocytes are arrested at metaphase I or telophase I. However, oocyte spindle structure and chromosome alignment are not disrupted after the inhibition of MKlp2 by paprotrain. Paprotrain-treated porcine oocytes suffer failure of nuclear maturation. The number of oocytes arrested at early MI stage increase in a dose-dependent manner after KIF20A activity inhibition, while the percentage of oocytes that reach ATI and MII stages decrease after treatment.
体内实验

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同义词

(alphaZ)-alpha-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile
通路

Cytoskeleton/Cell Adhesion Molecules
靶点

Kinesin
受体

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研究领域

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适应症

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