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COX-2-IN-1
CAS No. 787623-48-7
COX-2-IN-1 ( —— )
产品货号. M26018 CAS No. 787623-48-7
COX-2-IN-1 是一种有效的选择性 COX-2 抑制剂 (IC50: 3.9 μM)。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥1093 | 有现货 |
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| 5MG | ￥1701 | 有现货 |
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| 10MG | ￥2499 | 有现货 |
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| 25MG | ￥3850 | 有现货 |
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| 50MG | ￥5282 | 有现货 |
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| 100MG | ￥6912 | 有现货 |
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| 500MG | ￥13770 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥1872 | 有现货 |
|
生物学信息
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产品名称COX-2-IN-1
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述COX-2-IN-1 是一种有效的选择性 COX-2 抑制剂 (IC50: 3.9 μM)。
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产品描述COX-2-IN-1 is a potent and selective COX-2 inhibitor (IC50: 3.9 μM).(In Vitro):COX-2-IN-1(compound 5f) is an inhibitor of COX-1 and COX-2 with IC50s of >100 and 3.9 μM, respectively.
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体外实验COX-2-IN-1(compound5f) is an inhibitor of COX-1 and COX-2 withIC50sof>100 and 3.9 μM, respctively. Comparison of 5b and COX-2-IN-1 shows that smaller halogen atom at 5th position on the indole ring enhances COX-2 enzyme inhibition activity, whereas the presence of a larger bromine atom at 6th position of the ring improves the inhibitory activity (5d, 5e and 5h) of the compound.
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体内实验——
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同义词——
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通路Chromatin/Epigenetic
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靶点COX
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受体Alkyl-Chain
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研究领域——
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适应症——
化学信息
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CAS Number787623-48-7
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分子量442.84
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分子式C18H14ClF3N4O2S
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纯度>98% (HPLC)
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溶解度——
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SMILESNS(=O)(=O)c1ccc(cc1)N1N=C(CC1c1c[nH]c2c(Cl)cccc12)C(F)(F)F
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Yang J, et al. Simple Structural Modifications Converting a Bona fide MDM2 PROTAC Degrader into a Molecular Glue Molecule: A Cautionary Tale in the Design of PROTAC Degraders. J Med Chem. 2019 Oct 21.
