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AMN082
CAS No. 83027-13-8
AMN082 ( —— )
产品货号. M24820 CAS No. 83027-13-8
AMN082 是一种代谢型谷氨酸受体 7 变构激动剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥415 | 有现货 |
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| 10MG | ￥661 | 有现货 |
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| 25MG | ￥1293 | 有现货 |
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| 50MG | ￥2074 | 有现货 |
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| 100MG | ￥2871 | 有现货 |
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| 200MG | ￥3924 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
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| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥358 | 有现货 |
|
生物学信息
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产品名称AMN082
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述AMN082 是一种代谢型谷氨酸受体 7 变构激动剂。
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产品描述AMN082 is a metabotropic glutamate receptor 7 allosteric agonist.
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体外实验Preincubation of the synaptosomes with AMN082 (1 μM) for 10 min before 4-aminopyridine treatment efficiently inhibits the 4-aminopyridine-evoked release of glutamate, without altering the basal release of glutamate.
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体内实验AMN082 (6 mg/kg; p.o.) induces stress hormone increases in an mGluR7-dependent fashion in mGluR7+/+ mice (C57BL/6 genetic background).AMN082 (1.25-5.0 mg/kg, i.p.; 30 min before every Cocaine injection during repeated drug administration or before Cocaine challenge) dose-dependently attenuates the development, as well as the expression of Cocaine locomotor sensitization.
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同义词——
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通路Neuroscience
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靶点GluR
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受体mGluR7
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研究领域——
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适应症——
化学信息
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CAS Number83027-13-8
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分子量392.54
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分子式C28H28N2
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 12.5 mg/mL (31.84 mM)
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SMILESC(CNC(c1ccccc1)c1ccccc1)NC(c1ccccc1)c1ccccc1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Marszalek, M, Komsta, et al. AMN082, a metabotropic glutamate receptor 7 allosteric agonist, attenuates locomotor sensitization and cross-sensitization induced by cocaine and morphine in mice[J]. Progress in Neuro Psychopharmacology & Biological Psychiatry An International Research Review & News Journal, 2015.
