Hirsutine ( —— )

产品货号. M24776 CAS No. 7729-23-9

COA

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HNMR

HPLC

MSDS

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产品名称

Hirsutine
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Hirsutine 诱导细胞凋亡，是一种有效的登革热病毒抑制剂，具有低细胞毒性。
产品描述

Hirsutine induces apoptosis and is a potent Dengue virus inhibitor exhibiting low cytotoxicity.Hirsutine has anticancer, cardioprotective, anti-hypertensive and anti-arrhythmic activities, it also has vasodilatation activity, the mechanism is related to blockade of Ca2+ influx through L-type Ca2+ channels and inhibition of intracellular Ca2+ release may have no relationship with K+ channels.
体外实验

Hirsutine remarkably reduces the viability of MCF-7 and MDA-MB-231 cells in a time- and dose-dependent manner with IC50 values of 447.79 and 179.06 μM, respectively. In the MDA-MB-231 cells, Hirsutine induces apoptosis and depolarization of MMP, releases Cyt C from mitochondria, and activates caspase 9 and caspase 3.
体内实验

Hirsutine induces mPTP-dependent apoptosis through ROCK1/PTEN/PI3K/GSK3β pathway in human lung cancer cells.
同义词

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通路

Apoptosis
靶点

Apoptosis
受体

Apoptosis
研究领域

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适应症

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1.Selective anticancer activity of hirsutine against HER2-positive breast cancer cells by inducing DNA damage.Oncol Rep. 2015 Apr;33(4):2072-6.

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