Ketorolac

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

酮咯酸是杂环乙酸衍生物家族中的一种非甾体抗炎药 (NSAID)。它通过抑制体内前列腺素的合成来发挥作用。

Ketorolac is a non-steroidal anti-inflammatory drug (NSAID) in the family of heterocyclic acetic acid derivatives. It acts by inhibiting the bodily synthesis of prostaglandins.

Ketorolac (RS37619) salt (0-30 μM; 48 h) effectively kills the oral cancer cells.Ketorolac salt (0-5 μM; 48 h) inhibits the expression of DDX3 protein, and induces apoptosis in H357 cells.Ketorolac salt (0-2.5 μM; 0-16 h) inhibits the proliferation of oral cancer cells.Ketorolac salt (0-50 μM) directly interacts with DDX3 and inhibits the ATPase activity.Cell Viability Assay Cell Line:HOK, SCC4, SCC9 and H357 cells Concentration:0-30 μM Incubation Time:48 h Result:Showed inhibition with IC50s of 2.6, 7.1 and 8.1 μM against H357, SCC4 and SCC9 cells, respectively. And the normal HOK cell line did not show any cell death effect.Cell Proliferation Assay Cell Line:H357 Concentration:0.5, 1.0, 1.5, 2.0 and 2.5 μM Incubation Time:0, 8 and 16 h Result:Inhibited the proliferation.Western Blot Analysis Cell Line:H357 Concentration:1, 2.5 and 5 μM Incubation Time:48 h Result:Significantly reduced DDX3 protein expression levels, but not completely ablated as compared to DMSO treated cells. Up regulated the expression of E-cadherin.Apoptosis Analysis Cell Line:H357 Concentration:2.5 and 5 μM Incubation Time:48 hResult:Induced apoptosis.

Ketorolac (RS37619) (0.4% ketorolac tromethamine ophthalmic solution) shows powerful ocular anti-inflammatory activities in rabbits.Ketorolac (4 mg/kg/day, p.o.; 2 weeks) has no detrimental effect in the volume fraction of bone trabeculae formed inside the alveolar socket in rats.Ketorolac (60 μg; intrathecal injection; once) attenuates the damage caused by spinal cord ischemia in rats.Ketorolac salt (20 and 30 mg/kg; i.p.; two times in a week for 3 weeks) reduces oral carcinogenesis in mice. Animal Model:New Zealand White rabbits (2.0–2.7 kg), LPS endotoxin-induced ocular inflammation Dosage:50 μL ketorolac tromethamine ophthalmic solution 0.4%Administration:In eyes, twice, 2 hours and 1 hour before LPS challenge Result:Resulted in a nearly complete inhibition (98.7%) of LPS endotoxin-induced increases in FITC (fluorescein isothiocyanate)-dextran in the anterior chamber, and resulted in a nearly complete inhibition (97.5%) of LPS endotoxin-induced increases in aqueous PGE2 concentrations in the aqueous humor.Animal Model:Male Wistar rats (400–450 g), spinal cord ischemia model Dosage:30 and 60 μg Administration:Intrathecal injection, 1 h before the ischemia induction for once Result:Significantly reduced the motor disturbances and improved the survival rate at 60 μg.Animal Model:Significantly reduced the motor disturbances and improved the survival rate at 60 μg.Dosage:20 mg/kg and 30 mg/kg Administration:IP injection, two times in a week for 3 weeks Result:Decreased tumor burden, reduced expression of DDX3 and anti-apoptotic proteins (Bcl-2 and Mcl-1).

?RS37619 | Toradol | Acular | Sprix | Macril | Acuvail

Chromatin/Epigenetic

COX

COX-1|COX-2

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74103-06-3

255.27

C15H13NO3

>98% (HPLC)

DMSO: 70 mg/mL (274.22 mM; Need ultrasonic);H2O: 70 mg/mL (274.22 mM; Need ultrasonic)

O=C(C1C2=CC=C(C(C3=CC=CC=C3)=O)N2CC1)O

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(-20℃)

With Ice Pack

≥ 2 years